Receptor 1 fibroblastnog faktora rasta (FGFR1, receptor 1 bazičnog fibroblastnog faktora rasta, fms-srodna tirozinska kinaza-2 / Pfeiffer sindrom, i CD331) receptorska tirozinska kinaza je čiji ligandi su specifični članovi familije fibroblastnih faktora rasta. FGFR1 je asocirana sa Pfeiffer sindromom.[1]
Funkcija
Protein kodiran ovim genom je član familije receptora fibroblastnih faktora rasta (FGFR) među kojima je aminokiselinska sekvenca visoko konzervirana tokom evolucije. Članovi FGFR familije se međusobno razlikuju po nihovom afinitetu za ligande i tkivnoj distribuciji. Reprezentativni protein pune dužine se sastoji od ekstracelularnog regiona, sastavljenog od tri imunoglobulinu slična domena, jednog hidrofobnog jednoprolaznog membranskog segmenta i citoplazmatičnog tirozinskog kinaznog domena. Ekstracelularna porcija proteina interaguje sa fibroblastnim faktorima rasta, čime se pokreće signalna kaslada koja utiče na mitogenezu i diferencijaciju. Ovaj član familije se vezuje za kisele i bazne fibroblastne faktore rasta.
↑Itoh N, Terachi T, Ohta M, Seo MK (June 1990). „The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA”. Biochem. Biophys. Res. Commun.169 (2): 680–5. DOI:10.1016/0006-291X(90)90384-Y. PMID2162671.
↑Reilly JF, Mickey G, Maher PA (March 2000). „Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner”. J. Biol. Chem.275 (11): 7771–8. DOI:10.1074/jbc.275.11.7771. PMID10713090.
↑Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (April 1995). „Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins”. Oncogene10 (8): 1475–83. PMID7537362.
↑Yan KS, Kuti M, Yan S, Mujtaba S, Farooq A, Goldfarb MP, Zhou MM (May 2002). „FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors”. J. Biol. Chem.277 (19): 17088–94. DOI:10.1074/jbc.M107963200. PMID11877385.
↑Xu H, Lee KW, Goldfarb M (July 1998). „Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins”. J. Biol. Chem.273 (29): 17987–90. DOI:10.1074/jbc.273.29.17987. PMID9660748.
↑Dhalluin C, Yan KS, Plotnikova O, Lee KW, Zeng L, Kuti M, Mujtaba S, Goldfarb MP, Zhou MM (October 2000). „Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors”. Mol. Cell6 (4): 921–9. DOI:10.1016/S1097-2765(05)00087-0. PMID11090629.
↑Urakawa I, Jamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yameshita T (October 2006). „Klotho converts canonical FGF receptor into a specific receptor for FGF23”. Nature.444: 770–4. DOI:10.1038/nature05315. PMID7086194.
↑Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, Linhardt RJ, Mohammadi M (September 2000). „Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization”. Mol. Cell6 (3): 743–50. DOI:10.1016/S1097-2765(00)00073-3. PMID11030354.
↑Santos-Ocampo S, Colvin JS, Chellaiah A, Ornitz DM (January 1996). „Expression and biological activity of mouse fibroblast growth factor-9”. J. Biol. Chem.271 (3): 1726–31. DOI:10.1074/jbc.271.3.1726. PMID8576175.
Literatura
Weiss J, Sos ML, Seidel D i dr.. (December 2010). „Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer”. Sci Transl Med2 (62): 62ra93. DOI:10.1126/scitranslmed.3001451. PMID21160078.
Macdonald D, Reiter A, Cross NC (2002). „The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1”. Acta Haematol.107 (2): 101–7. DOI:10.1159/000046639. PMID11919391.
Groth C, Lardelli M (2003). „The structure and function of vertebrate fibroblast growth factor receptor 1”. Int. J. Dev. Biol.46 (4): 393–400. PMID12141425.
Wilkie AO (2005). „Bad bones, absent smell, selfish testes: the pleiotropic consequences of human FGF receptor mutations”. Cytokine Growth Factor Rev.16 (2): 187–203. DOI:10.1016/j.cytogfr.2005.03.001. PMID15863034.