edit

Janus kinaza 3

PDB prikaz baziran na 1yvj.

Dostupne strukture

1YVJ, 3LXK, 3LXL, 3PJC, 3ZC6, 3ZEP, 4HVD, 4HVG, 4HVH, 4HVI, 4I6Q

Identifikatori

Simboli

JAK3; JAK-3; JAK3_HUMAN; JAKL; L-JAK; LJAK

Vanjski ID

OMIM: 600173 MGI: 99928 HomoloGene: 181 GeneCards: JAK3 Gene

EC broj

2.7.10.2

Ontologija gena
Molekulska funkcija	• aktivnost proteinske tirozinske kinaze • aktivnost nemembranske proteinske tirozinske kinaze • proteinsko vezivanje
Ćelijska komponenta	• citozol • citoskeleton • endomembranski sistem
Biološki proces	• negativna regulacija citokinske produkcije dendritskih ćelija • proteinska fosforilacija • tirozinska fosforilacija STAT proteina

Ortolozi

Vrsta

Čovek

Miš

Ref. Sekv. (iRNK)

Ref. Sekv. (protein)

Lokacija (UCSC)

Chr 19:
17.94 - 17.96 Mb

Chr 8:
71.68 - 71.69 Mb

PubMed pretraga

[1]

[2]

Tirozinska proteinska kinaza JAK3 je enzim koji je kod ljudi kodiran JAK3 genom.^[1]^[2]

Regulacija

Janus kinaza 3 formira interakcije sa CD247,^[3] TIAF1^[4] i IL2RG.^[5]^[6]

Reference

↑ Riedy MC, Dutra AS, Blake TB, Modi W, Lal BK, Davis J, Bosse A, O'Shea JJ, Johnston JA (February 1997). „Genomic sequence, organization, and chromosomal localization of human JAK3”. Genomics 37 (1): 57–61. DOI:10.1006/geno.1996.0520. PMID 8921370.
↑ Hoffman SM, Lai KS, Tomfohrde J, Bowcock A, Gordon LA, Mohrenweiser HW (September 1997). „JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors”. Genomics 43 (1): 109–11. DOI:10.1006/geno.1997.4792. PMID 9226382.
↑ Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T (July 2001). „Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex”. J. Biol. Chem. 276 (27): 25378–85. DOI:10.1074/jbc.M011363200. PMID 11349123.
↑ Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z (April 2000). „A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival”. Biochem. Biophys. Res. Commun. 270 (1): 267–71. DOI:10.1006/bbrc.2000.2413. PMID 10733938.
↑ Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). „Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits”. Science 266 (5187): 1045–7. DOI:10.1126/science.7973659. PMID 7973659.
↑ Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). „Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID”. Science 266 (5187): 1042–5. DOI:10.1126/science.7973658. PMID 7973658.

Literatura

Notarangelo LD, Mella P, Jones A, de Saint Basile G, Savoldi G, Cranston T, Vihinen M, Schumacher RF (October 2001). „Mutations in severe combined immune deficiency (SCID) due to JAK3 deficiency”. Hum. Mutat. 18 (4): 255–63. DOI:10.1002/humu.1188. PMID 11668610.
Russell SM, Tayebi N, Nakajima H, Riedy MC, Roberts JL, Aman MJ, Migone TS, Noguchi M, Markert ML, Buckley RH, O'Shea JJ, Leonard WJ (November 1995). „Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development”. Science 270 (5237): 797–800. DOI:10.1126/science.270.5237.797. PMID 7481768.
Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995). „Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases”. J. Biol. Chem. 270 (48): 28527–30. DOI:10.1074/jbc.270.48.28527. PMID 7499365.
Musso T, Johnston JA, Linnekin D, Varesio L, Rowe TK, O'Shea JJ, McVicar DW (April 1995). „Regulation of JAK3 expression in human monocytes: phosphorylation in response to interleukins 2, 4, and 7”. J. Exp. Med. 181 (4): 1425–31. DOI:10.1084/jem.181.4.1425. PMC 2191962. PMID 7535338.
Rolling C, Treton D, Beckmann P, Galanaud P, Richard Y (May 1995). „JAK3 associates with the human interleukin 4 receptor and is tyrosine phosphorylated following receptor triggering”. Oncogene 10 (9): 1757–61. PMID 7538655.
Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET (October 1995). „A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells”. J. Biol. Chem. 270 (42): 25028–36. DOI:10.1074/jbc.270.42.25028. PMID 7559633.
Macchi P, Villa A, Giliani S, Sacco MG, Frattini A, Porta F, Ugazio AG, Johnston JA, Candotti F, O'Shea JJ (September 1995). „Mutations of Jak-3 gene in patients with autosomal severe combined immune deficiency (SCID)”. Nature 377 (6544): 65–8. DOI:10.1038/377065a0. PMID 7659163.
Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). „Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID”. Science 266 (5187): 1042–5. DOI:10.1126/science.7973658. PMID 7973658.
Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). „Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits”. Science 266 (5187): 1045–7. DOI:10.1126/science.7973659. PMID 7973659.
Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ (July 1994). „Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2”. Nature 370 (6485): 151–3. DOI:10.1038/370151a0. PMID 8022485.
Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN (July 1994). „Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells”. Nature 370 (6485): 153–7. DOI:10.1038/370153a0. PMID 8022486.
Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR (July 1994). „Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes”. Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6374–8. DOI:10.1073/pnas.91.14.6374. PMC 44204. PMID 8022790.
Verbsky JW, Bach EA, Fang YF, Yang L, Randolph DA, Fields LE (June 1996). „Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells”. J. Biol. Chem. 271 (24): 13976–80. DOI:10.1074/jbc.271.24.13976. PMID 8662778.
Fusaki N, Iwamatsu A, Iwashima M, Fujisawa J (March 1997). „Interaction between Sam68 and Src family tyrosine kinases, Fyn and Lck, in T cell receptor signaling”. J. Biol. Chem. 272 (10): 6214–9. DOI:10.1074/jbc.272.10.6214. PMID 9045636.
Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997). „An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT”. Oncogene 14 (7): 751–61. DOI:10.1038/sj.onc.1200907. PMID 9047382.
Safford MG, Levenstein M, Tsifrina E, Amin S, Hawkins AL, Griffin CA, Civin CI, Small D (May 1997). „JAK3: expression and mapping to chromosome 19p12-13.1”. Exp. Hematol. 25 (5): 374–86. PMID 9168059.
Sharfe N, Dadi HK, O'Shea JJ, Roifman CM (June 1997). „Jak3 activation in human lymphocyte precursor cells”. Clin. Exp. Immunol. 108 (3): 552–6. DOI:10.1046/j.1365-2249.1997.4001304.x. PMC 1904698. PMID 9182906.
Candotti F, Oakes SA, Johnston JA, Giliani S, Schumacher RF, Mella P, Fiorini M, Ugazio AG, Badolato R, Notarangelo LD, Bozzi F, Macchi P, Strina D, Vezzoni P, Blaese RM, O'Shea JJ, Villa A (November 1997). „Structural and functional basis for JAK3-deficient severe combined immunodeficiency”. Blood 90 (10): 3996–4003. PMID 9354668.

Vanjske veze

MeSH Janus+Kinase+3

PDB Galerija

1yvj: Kristalna struktura Jak3 kinaznog domena u kompleksu sa staurosporinskim analogom

Proteinske kinaze: Tirozinske kinaze (EC 2.7.10)

Receptorske tirozinske kinaze (EC 2.7.10.1)

Receptori faktora rasta

EGF receptorska familija	EGFR • ERBB2 • ERBB3 • ERBB4
Insulinska receptorska familija	IGF1R • INSR • INSRR
PDGF receptorska familija	CSF1R • FLT3 • KIT • PDGFR (PDGFRA, PDGFRB)
FGF receptorska familija	FGFR1 • FGFR2 • FGFR3 • FGFR4
VEGF receptorska familija	VEGFR1 • VEGFR2 • VEGFR3 • VEGFR4
HGF receptorska familija	MET • RON
Trk receptorska familija	NTRK1 • NTRK2 • NTRK3

EPH receptorska familija

EPHA1 • EPHA2 • EPHA3 • EPHA4 • EPHA5 • EPHA6 • EPHA7 • EPHA8 • EPHB1 • EPHB2 • EPHB3 • EPHB4 • EPHB5 • EPHB6 • EPHX

LTK receptorska familija

LTK • ALK

TIE receptorska familija

TIE • TEK

ROR receptorska familija

ROR1 • ROR2

DDR receptorska familija

DDR1 • DDR2

PTK7 receptorska familija

PTK7

RYK receptorska familija

RYK

MuSK receptorska familija

MUSK

ROS receptorska familija

ROS1

AATYK receptorska familija

AATYK • AATYK2 • AATYK3

AXL receptorska familija

AXL • MER • TYRO3

RET receptorska familija

RET

nekategorisani

STYK1

Nereceptorske tirozinske kinaze (EC 2.7.10.2)

ABL familija	ABL1 • ARG
ACK familija	ACK1 • TNK1
CSK familija	CSK • MATK
FAK familija	FAK • PYK2
FES familija	FES • FER
FRK familija	FRK • BRK • SRMS
JAK familija	JAK1 • JAK2 • JAK3 • TYK2
SRC-A familija	SRC • FGR • FYN • YES1
SRC-B familija	BLK • HCK • LCK • LYN
TEC familija	TEC • BMX • BTK • ITK • TXK
SYK familija	SYK • ZAP70

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Kategorije