Proto-onkogena tirozinska proteinska kinaza FER je enzim koji je kod ljudi kodiran FERgenom.[1]
Fer protein je član FPS/FES familije netransmembranskih receptorskih tirozinskih kinaza. On reguliše međućelijsku adheziju i posreduje signalizaciju sa ćelijske površine na citoskeleton putem receptora faktora rasta.[1]
↑Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). „Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases”. FEBS Lett. (NETHERLANDS) 434 (3): 339–45. DOI:10.1016/S0014-5793(98)01003-5. ISSN0014-5793. PMID9742951.
↑Kim, L; Wong T W (Sep 1998). „Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER”. J. Biol. Chem. (UNITED STATES) 273 (36): 23542–8. DOI:10.1074/jbc.273.36.23542. ISSN0021-9258. PMID9722593.
Greer P (2002). „Closing in on the biological functions of Fps/Fes and Fer”. Nat. Rev. Mol. Cell Biol.3 (4): 278–89. DOI:10.1038/nrm783. PMID11994747.
Nishisho I, Nakamura Y, Miyoshi Y, et al. (1991). „Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients”. Science253 (5020): 665–9. DOI:10.1126/science.1651563. PMID1651563.
Warrington JA, Hall LV, Hinton LM, et al. (1992). „Radiation hybrid map of 13 loci on the long arm of chromosome 5”. Genomics11 (3): 701–8. DOI:10.1016/0888-7543(91)90078-S. PMID1663488.
Morris C, Heisterkamp N, Hao QL, et al. (1990). „The human tyrosine kinase gene (FER) maps to chromosome 5 and is deleted in myeloid leukemias with a del(5q)”. Cytogenet. Cell Genet.53 (4): 196–200. DOI:10.1159/000132929. PMID2209086.
Brunati AM, Pinna LA (1988). „Characterization of four tyrosine protein kinases from the particulate fraction of rat spleen”. Eur. J. Biochem.172 (2): 451–7. DOI:10.1111/j.1432-1033.1988.tb13909.x. PMID3350007.
Meggio F, Brunati AM, Pinna LA (1987). „Polycation-dependent, Ca2+-antagonized phosphorylation of calmodulin by casein kinase-2 and a spleen tyrosine protein kinase”. FEBS Lett.215 (2): 241–6. DOI:10.1016/0014-5793(87)80154-0. PMID3472906.
Kim L, Wong TW (1998). „Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the cytoplasmic tyrosine kinase FER”. J. Biol. Chem.273 (36): 23542–8. DOI:10.1074/jbc.273.36.23542. PMID9722593.
Schwartz Y, Ben-Dor I, Navon A, et al. (1998). „Tyrosine phosphorylation of the TATA element modulatory factor by the FER nuclear tyrosine kinases”. FEBS Lett.434 (3): 339–45. DOI:10.1016/S0014-5793(98)01003-5. PMID9742951.
Huang C, Liu J, Haudenschild CC, Zhan X (1998). „The role of tyrosine phosphorylation of cortactin in the locomotion of endothelial cells”. J. Biol. Chem.273 (40): 25770–6. DOI:10.1074/jbc.273.40.25770. PMID9748248.
Corti C, Leclerc L'Hostis E, Quadroni M, et al. (1999). „Tyrosine phosphorylation modulates the interaction of calmodulin with its target proteins”. Eur. J. Biochem.262 (3): 790–802. DOI:10.1046/j.1432-1327.1999.00441.x. PMID10411641.
Priel-Halachmi S, Ben-Dor I, Shpungin S, et al. (2000). „FER kinase activation of Stat3 is determined by the N-terminal sequence”. J. Biol. Chem.275 (37): 28902–10. DOI:10.1074/jbc.M003402200. PMID10878010.
Kapus A, Di Ciano C, Sun J, et al. (2000). „Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases”. J. Biol. Chem.275 (41): 32289–98. DOI:10.1074/jbc.M003172200. PMID10921917.
Orlovsky K, Ben-Dor I, Priel-Halachmi S, et al. (2000). „N-terminal sequences direct the autophosphorylation states of the FER tyrosine kinases in vivo”. Biochemistry39 (36): 11084–91. DOI:10.1021/bi0005153. PMID10998246.