Tirotropin-oslobađajući hormonski receptor

Identifikatori

TRHR; MGC141920

Vanjski ID

OMIM: 188545 MGI: 98824 HomoloGene: 20707 IUPHAR: TRH₁ GeneCards: TRHR Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu-sličnog receptor • receptorska aktivnost • aktivnost tirotropin-oslobađajućeg hormonskog receptora
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 8:
110.17 - 110.2 Mb

Chr 15:
44.03 - 44.06 Mb

PubMed pretraga

[1]

[2]

TRHR (tirotropin-oslobađajući hormonski receptor) je G protein-spregnuti receptor koji vezuje tripeptid tireotropin oslobađajući hormon.^[1]^[2] TRHR je nađen u mozgu. Kad je ovaj receptor vezan za TRH dejstvuje kroz fosfolipazu C i povišava intracelularnu koncentraciju inozitol trifosfata.

Reference

[uredi | uredi kod]

↑ Yamada M, Monden T, Konaka S, Mori M (1993). „Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8”. Somat. Cell Mol. Genet. 19 (6): 577–80. DOI:10.1007/BF01233384. PMID 8128317.
↑ Gershengorn MC (1993). „Thyrotropin-releasing hormone receptor: cloning and regulation of its expression”. Recent Prog. Horm. Res. 48: 341–63. PMID 8382829.

Literatura

[uredi | uredi kod]

Short RE, James LF, Panter KE, et al. (1993). „Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep.”. J. Anim. Sci. 70 (11): 3498–504. PMID 1459912.
Yamada M, Iwasaki T, Satoh T, et al. (1996). „Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly.”. Neurosci. Lett. 196 (1-2): 109–12. DOI:10.1016/0304-3940(95)11861-P. PMID 7501234.
Hinuma S, Hosoya M, Ogi K, et al. (1994). „Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene.”. Biochim. Biophys. Acta 1219 (2): 251–9. PMID 7918619.
Morrison N, Duthie SM, Boyd E, et al. (1994). „Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization.”. Hum. Genet. 93 (6): 716–8. PMID 8005602.
Yamada M, Monden T, Konaka S, Mori M (1994). „Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8.”. Somat. Cell Mol. Genet. 19 (6): 577–80. DOI:10.1007/BF01233384. PMID 8128317.
Duthie SM, Taylor PL, Anderson L, et al. (1994). „Cloning and functional characterisation of the human TRH receptor.”. Mol. Cell. Endocrinol. 95 (1-2): R11–5. DOI:10.1016/0303-7207(93)90043-J. PMID 8243797.
Matre V, Karlsen HE, Wright MS, et al. (1993). „Molecular cloning of a functional human thyrotropin-releasing hormone receptor.”. Biochem. Biophys. Res. Commun. 195 (1): 179–85. DOI:10.1006/bbrc.1993.2027. PMID 8395824.
Yamada M, Monden T, Satoh T, et al. (1993). „Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene.”. Biochem. Biophys. Res. Commun. 195 (2): 737–45. DOI:10.1006/bbrc.1993.2107. PMID 8396925.
Iwasaki T, Yamada M, Satoh T, et al. (1996). „Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene.”. J. Biol. Chem. 271 (36): 22183–8. DOI:10.1074/jbc.271.36.22183. PMID 8703031.
Cook JV, McGregor A, Lee T, et al. (1996). „A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.”. Endocrinology 137 (7): 2851–8. DOI:10.1210/en.137.7.2851. PMID 8770906.
Collu R, Tang J, Castagné J, et al. (1997). „A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene.”. J. Clin. Endocrinol. Metab. 82 (5): 1561–5. DOI:10.1210/jc.82.5.1561. PMID 9141550.
Petrou C, Tashjian AH (1999). „The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles.”. Cell. Signal. 10 (8): 553–9. DOI:10.1016/S0898-6568(97)00190-3. PMID 9794253.
Matre V, Høvring PI, Orstavik S, et al. (1999). „Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor.”. J. Neurochem. 72 (1): 40–50. DOI:10.1046/j.1471-4159.1999.0720040.x. PMID 9886052.
Kroeger KM, Hanyaloglu AC, Seeber RM, et al. (2001). „Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer.”. J. Biol. Chem. 276 (16): 12736–43. DOI:10.1074/jbc.M011311200. PMID 11278883.
Zhu CC, Cook LB, Hinkle PM (2002). „Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation.”. J. Biol. Chem. 277 (31): 28228–37. DOI:10.1074/jbc.M204221200. PMID 12023974.
Hanyaloglu AC, Seeber RM, Kohout TA, et al. (2003). „Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2.”. J. Biol. Chem. 277 (52): 50422–30. DOI:10.1074/jbc.M209340200. PMID 12393857.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cook LB, Zhu CC, Hinkle PM (2004). „Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation.”. Mol. Endocrinol. 17 (9): 1777–91. DOI:10.1210/me.2003-0073. PMID 12805411.
Igarashi-Migitaka J, Yamada S, Hara M, et al. (2004). „Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas.”. Endocr. J. 50 (4): 459–67. DOI:10.1507/endocrj.50.459. PMID 14599121.
Cook LB, Hinkle PM (2004). „Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein.”. Endocrinology 145 (7): 3095–100. DOI:10.1210/en.2004-0304. PMID 15117874.

Spoljašnje veze

[uredi | uredi kod]

„Thyrotropin-Releasing Hormone Receptors”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2012-09-08.
MeSH Receptors,+Thyrotropin-Releasing+Hormone

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Peptidi: Neuropeptidi

Hormoni

vidi hormoni

Opioidni peptidi

Dinorfin	Veliki dinorfin • Dinorfin A • Dinorfin B
Endorfin	Alfa-endorfin • Beta-endorfin • Gama-endorfin • α-neo-endorfin • β-neo-endorfin
Enkefalin	Met-enkefalin • Leu-enkefalin
Drugi	Adrenorfin • Amidorfin • Nociceptin • Opiorfin

Drugi neuropeptidi

Kinini	Bradikinin Tahikinini: sisari (Supstanca P, Neurokinin A, Neurokinin B) • vodozemaci (Kasinin, Fisalaemin)
Neuromedini	B • N • S • U
Drugi	Angiotenzin • Bombezin • Peptid srodan kalcitoninu • Karnozin • Kokainom i amfetaminom regulisani transkript • Peptid indukovanja delta sna • FMRF amid • Galanin • Galaninu sličan peptid • Peptid oslobađanja gastrina • Neuropeptid S • Neuropeptid Y • Neurofizini • Neurotenzin • Pankreatični polipeptid • Aktivirajući peptid hipofizne adenilat ciklaze • RVD-Hpα • VGF