Gonadotropin-oslobađajući hormonski receptor II

Identifikatori

GNRHR2; GnRH-II-R

Vanjski ID

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora • receptorska aktivnost • aktivnost receptora gonadotropin oslobađajućeg hormona
Celularna komponenta	• membrana • integralno sa membranom
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora

Ortolozi

Vrsta

Čovek

Miš

n/a

n/a

n/a

RefSeq (mRNA)

NR_002328

n/a

RefSeq (protein)

n/a

Lokacija (UCSC)

Chr 1:
145.51 - 145.52 Mb

n/a

PubMed pretraga

[1]

n/a

GNRHR2, gonadotropin-oslobađajući hormonski receptor II, je protein koji je kod ljudi kodiran GNRHR2 genom.^[1]^[2]

Receptor gonadotropin oslobađajućeg hormona 2 (GnRH2) je G protein spregnuti receptor, koji je kodiran GnRHR2 genom kod ne-hominoidnih primata i ne-sisarskih kičmenjaka. Kod ljudi, N-terminus protein ima pomeranje okvira čitanja sekvence i prerani stop kodon. Mada dolazi do transkripcije, još uvek nije potpuno razjašnjeno da li je receptor funkcionalan. Alternativne splajsne varijante su poznate. Nentranskribovani GnRHR2 pseudogen takođe postoji na hromozomu 14.^[2]

Povezano

[uredi | uredi kod]

Reference

[uredi | uredi kod]

↑ Faurholm B, Millar RP, Katz AA (Nov 2001). „The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci”. Genomics 78 (1–2): 15–8. DOI:10.1006/geno.2001.6650. PMID 11707068.
↑ ^2,0 ^2,1 „Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2”.

Literatura

[uredi | uredi kod]

Neill JD (2002). „GnRH and GnRH receptor genes in the human genome”. Endocrinology 143 (3): 737–43. DOI:10.1210/en.143.3.737. PMID 11861490.
Millar R, Conklin D, Lofton-Day C, et al. (1999). „A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript”. J. Endocrinol. 162 (1): 117–26. DOI:10.1677/joe.0.1620117. PMID 10396028.
Neill JD, Duck LW, Sellers JC, Musgrove LC (2001). „A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates”. Biochem. Biophys. Res. Commun. 282 (4): 1012–8. DOI:10.1006/bbrc.2001.4678. PMID 11352653.
van Biljon W, Wykes S, Scherer S, et al. (2003). „Type II gonadotropin-releasing hormone receptor transcripts in human sperm”. Biol. Reprod. 67 (6): 1741–9. DOI:10.1095/biolreprod.101.002808. PMID 12444048.
Morgan K, Conklin D, Pawson AJ, et al. (2003). „A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12”. Endocrinology 144 (2): 423–36. DOI:10.1210/en.2002-220622. PMID 12538601.
Pawson AJ, Maudsley S, Morgan K, et al. (2005). „Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment”. Endocrinology 146 (6): 2639–49. DOI:10.1210/en.2005-0133. PMID 15761034.
Eicke N, Günthert AR, Viereck V, et al. (2005). „GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs”. Eur. J. Endocrinol. 153 (4): 605–12. DOI:10.1530/eje.1.02005. PMID 16189182.
Ikemoto T, Park MK (2006). „Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors”. Genomics 87 (4): 459–62. DOI:10.1016/j.ygeno.2005.11.005. PMID 16406723.
Parker JD, Malik M, Catherino WH (2007). „Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor”. Fertil. Steril. 88 (1): 39–46. DOI:10.1016/j.fertnstert.2006.11.098. PMID 17296196.

Spoljašnje veze

[uredi | uredi kod]

„Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.

Transmembranski receptor: G protein spregnuti receptori

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Drugi

Moždano specifični angiogenezni inhibitor (1, 2, 3) • Cadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta oslobađajući hormon • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuselah-slični proteini • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4)

Klasa F:
Frizzled / Zaglađeni

Uvojiti	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni	Zaglađeni

B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)