Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[5][6]
HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone.[7][8] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[9] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[10]