Zinc finger protein 217, also known as ZNF217, is a protein which in humans is encoded by the ZNF217gene.[5][6]
Function
ZNF217 can attenuate apoptotic signals resulting from telomere dysfunction and may promote neoplastic transformation and later stages of malignancy.[7] Znf217 was shown to be a prognostic biomarker and therapeutic target during breast cancer progression.[8]
Nonet GH, Stampfer MR, Chin K, Gray JW, Collins CC, Yaswen P (Feb 2001). "The ZNF217 gene amplified in breast cancers promotes immortalization of human mammary epithelial cells". Cancer Research. 61 (4): 1250–4. PMID11245413.
Weiss MM, Snijders AM, Kuipers EJ, Ylstra B, Pinkel D, Meuwissen SG, van Diest PJ, Albertson DG, Meijer GA (Jul 2003). "Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization". The Journal of Pathology. 200 (3): 320–6. doi:10.1002/path.1359. PMID12845628. S2CID10753746.
Shimada M, Imura J, Kozaki T, Fujimori T, Asakawa S, Shimizu N, Kawaguchi R (Apr 2005). "Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization". Oncology Reports. 13 (4): 633–41. doi:10.3892/or.13.4.633. PMID15756435.
Cowger JJ, Zhao Q, Isovic M, Torchia J (May 2007). "Biochemical characterization of the zinc-finger protein 217 transcriptional repressor complex: identification of a ZNF217 consensus recognition sequence". Oncogene. 26 (23): 3378–86. doi:10.1038/sj.onc.1210126. PMID17130829. S2CID19636585.