Protein-coding gene in the species Homo sapiens
GTF2H1 Identifiers Aliases GTF2H1 , BTF2, P62, TFB1, TFIIH, general transcription factor IIH subunit 1External IDs OMIM : 189972 ; MGI : 1277216 ; HomoloGene : 3885 ; GeneCards : GTF2H1 ; OMA :GTF2H1 - orthologs Gene ontology Molecular function Cellular component Biological process
termination of RNA polymerase I transcription
regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
transcription by RNA polymerase II
transcription, DNA-templated
cellular response to DNA damage stimulus
global genome nucleotide-excision repair
transcription-coupled nucleotide-excision repair
transcription initiation from RNA polymerase II promoter
nucleotide-excision repair, DNA incision
DNA repair
positive regulation of transcription by RNA polymerase II
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair
nucleotide-excision repair, DNA incision, 5'-to lesion
nucleotide-excision repair, preincision complex assembly
transcription by RNA polymerase I
phosphorylation of RNA polymerase II C-terminal domain
nucleotide-excision repair, DNA duplex unwinding
nucleotide-excision repair, DNA incision, 3'-to lesion
transcription elongation from RNA polymerase I promoter
Sources:Amigo / QuickGO
Wikidata
General transcription factor IIH subunit 1 is a protein that in humans is encoded by the GTF2H1 gene .[5] [6] [7]
GTF2H1 has been shown to interact with:
^ a b c ENSG00000288114 GRCh38: Ensembl release 89: ENSG00000110768, ENSG00000288114 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006599 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Fischer L, Gerard M, Chalut C, Lutz Y, Humbert S, Kanno M, Chambon P, Egly JM (October 1992). "Cloning of the 62-kilodalton component of basic transcription factor BTF2". Science . 257 (5075): 1392–5. Bibcode :1992Sci...257.1392F . doi :10.1126/science.1529339 . PMID 1529339 .
^ Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC (May 1994). "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet . 3 (1): 61–4. doi :10.1093/hmg/3.1.61 . PMID 8162052 .
^ "Entrez Gene: GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa" .
^ a b c Rossignol M, Kolb-Cheynel I, Egly JM (April 1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH" . EMBO J . 16 (7): 1628–37. doi :10.1093/emboj/16.7.1628 . PMC 1169767 . PMID 9130708 .
^ Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature . 374 (6519): 283–7. Bibcode :1995Natur.374..283S . doi :10.1038/374283a0 . PMID 7533895 . S2CID 4282418 .
^ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor". Cancer Res . 55 (24): 6058–62. PMID 8521393 .
^ Vandel L, Kouzarides T (August 1999). "Residues phosphorylated by TFIIH are required for E2F-1 degradation during S-phase" . EMBO J . 18 (15): 4280–91. doi :10.1093/emboj/18.15.4280 . PMC 1171504 . PMID 10428966 .
^ Drapkin R, Reardon JT, Ansari A, Huang JC, Zawel L, Ahn K, Sancar A, Reinberg D (April 1994). "Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II". Nature . 368 (6473): 769–72. Bibcode :1994Natur.368..769D . doi :10.1038/368769a0 . PMID 8152490 . S2CID 4363484 .
^ Chen D, Riedl T, Washbrook E, Pace PE, Coombes RC, Egly JM, Ali S (July 2000). "Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7". Mol. Cell . 6 (1): 127–37. doi :10.1016/s1097-2765(00)00014-9 . PMID 10949034 .
^ Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO" . J. Biol. Chem . 273 (42): 27593–601. doi :10.1074/jbc.273.42.27593 . PMID 9765293 .
^ Pan G, Aso T, Greenblatt J (September 1997). "Interaction of elongation factors TFIIS and elongin A with a human RNA polymerase II holoenzyme capable of promoter-specific initiation and responsive to transcriptional activators" . J. Biol. Chem . 272 (39): 24563–71. doi :10.1074/jbc.272.39.24563 . PMID 9305922 .
^ Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (July 2004). "A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A" . Nat. Genet . 36 (7): 714–9. doi :10.1038/ng1387 . PMID 15220921 .
^ Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (March 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH" . EMBO J . 16 (5): 1093–102. doi :10.1093/emboj/16.5.1093 . PMC 1169708 . PMID 9118947 .
Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci . 5 (1): 24–7. doi :10.1007/BF02253352 . PMID 9570510 .
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation" . Curr. Biol . 8 (13): R447-9. Bibcode :1998CBio....8.R447Y . doi :10.1016/S0960-9822(98)70289-1 . PMID 9651670 . S2CID 15480646 .
Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH". Nature . 374 (6519): 283–7. Bibcode :1995Natur.374..283S . doi :10.1038/374283a0 . PMID 7533895 . S2CID 4282418 .
Tong X, Drapkin R, Reinberg D, Kieff E (1995). "The 62- and 80-kDa subunits of transcription factor IIH mediate the interaction with Epstein-Barr virus nuclear protein 2" . Proc. Natl. Acad. Sci. U.S.A . 92 (8): 3259–63. Bibcode :1995PNAS...92.3259T . doi :10.1073/pnas.92.8.3259 . PMC 42145 . PMID 7724549 .
Fantes JA, Oghene K, Boyle S, Danes S, Fletcher JM, Bruford EA, Williamson K, Seawright A, Schedl A, Hanson I (1995). "A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1". Genomics . 25 (2): 447–61. doi :10.1016/0888-7543(95)80045-N . PMID 7789978 .
Xiao H, Pearson A, Coulombe B, Truant R, Zhang S, Regier JL, Triezenberg SJ, Reinberg D, Flores O, Ingles CJ (1994). "Binding of basal transcription factor TFIIH to the acidic activation domains of VP16 and p53" . Mol. Cell. Biol . 14 (10): 7013–24. doi :10.1128/mcb.14.10.7013 . PMC 359231 . PMID 7935417 .
Schaeffer L, Moncollin V, Roy R, Staub A, Mezzina M, Sarasin A, Weeda G, Hoeijmakers JH, Egly JM (1994). "The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor" . EMBO J . 13 (10): 2388–92. doi :10.1002/j.1460-2075.1994.tb06522.x . PMC 395103 . PMID 8194528 .
Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (1996). "Three functional classes of transcriptional activation domain" . Mol. Cell. Biol . 16 (5): 2044–55. doi :10.1128/MCB.16.5.2044 . PMC 231191 . PMID 8628270 .
Iyer N, Reagan MS, Wu KJ, Canagarajah B, Friedberg EC (1996). "Interactions involving the human RNA polymerase II transcription/nucleotide excision repair complex TFIIH, the nucleotide excision repair protein XPG, and Cockayne syndrome group B (CSB) protein". Biochemistry . 35 (7): 2157–67. doi :10.1021/bi9524124 . PMID 8652557 .
Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ (1996). "Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH" . Proc. Natl. Acad. Sci. U.S.A . 93 (13): 6482–7. Bibcode :1996PNAS...93.6482R . doi :10.1073/pnas.93.13.6482 . PMC 39049 . PMID 8692841 .
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (1996). "Human cyclin-dependent kinase-activating kinase exists in three distinct complexes" . Proc. Natl. Acad. Sci. U.S.A . 93 (13): 6488–93. Bibcode :1996PNAS...93.6488D . doi :10.1073/pnas.93.13.6488 . PMC 39050 . PMID 8692842 .
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science . 274 (5287): 605–10. Bibcode :1996Sci...274..605Z . doi :10.1126/science.274.5287.605 . PMID 8849451 . S2CID 13266489 .
Parada CA, Roeder RG (1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain". Nature . 384 (6607): 375–8. Bibcode :1996Natur.384..375P . doi :10.1038/384375a0 . PMID 8934526 . S2CID 4278432 .
García-Martínez LF, Ivanov D, Gaynor RB (1997). "Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes" . J. Biol. Chem . 272 (11): 6951–8. doi :10.1074/jbc.272.11.6951 . PMID 9054383 .
Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH" . EMBO J . 16 (5): 1093–102. doi :10.1093/emboj/16.5.1093 . PMC 1169708 . PMID 9118947 .
Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM (1997). "The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme" . Mol. Cell. Biol . 17 (4): 1817–23. doi :10.1128/mcb.17.4.1817 . PMC 232028 . PMID 9121429 .
Rossignol M, Kolb-Cheynel I, Egly JM (1997). "Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH" . EMBO J . 16 (7): 1628–37. doi :10.1093/emboj/16.7.1628 . PMC 1169767 . PMID 9130708 .
García-Martínez LF, Mavankal G, Neveu JM, Lane WS, Ivanov D, Gaynor RB (1997). "Purification of a Tat-associated kinase reveals a TFIIH complex that modulates HIV-1 transcription" . EMBO J . 16 (10): 2836–50. doi :10.1093/emboj/16.10.2836 . PMC 1169892 . PMID 9184228 .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group C bHLH-PAS Group D Group E Group F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4) β-Scaffold factors with minor groove contacts
(0) Other transcription factors
This article incorporates text from the United States National Library of Medicine , which is in the public domain .