Tetratricopeptide repeat domain 8 (TTC8) also known as Bardet–Biedl syndrome 8 is a protein that in humans is encoded by the TTC8 gene.[5]
TTC8 is associated with gamma-tubulin, BBS4, and PCM1 in the centrosome.[5] PCM1 in turn is involved in centriolar replication during ciliogenesis.[6]
TTC8 is located in the cilia of spermatids, retina, and bronchial epithelium cells.[5]
Mutations in the TTC8 gene is one of 14 genes[7] identified as causal for Bardet–Biedl syndrome.[5][8]