Chemical compound
Methallenestril Trade names Cur-men, Ercostrol, Geklimon, Novestrine, Vallestril (also spelled Vallestrol or Vallestryl) Other names Methallenoestril; Methallenestrol; Methallenoestrol; Horeau's acid; Allenestrol 6-methyl ether; α,α-Dimethyl-β-ethylallenolic acid 6-methyl ether; β-Ethyl-6-methoxy-α,α-dimethyl-2-naphthalenepropionic acid Routes of administration By mouth Drug class Nonsteroidal estrogen ATC code
3-(6-Methoxynaphthalen-2-yl)-2,2-dimethylpentanoic acid
CAS Number PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) ECHA InfoCard 100.007.485 Formula C 18 H 22 O 3 Molar mass 286.371 g·mol−1 3D model (JSmol )
CCC(c1ccc2cc(OC)ccc2c1)C(C)(C)C(=O)O
InChI=1S/C18H22O3/c1-5-16(18(2,3)17(19)20)14-7-6-13-11-15(21-4)9-8-12(13)10-14/h6-11,16H,5H2,1-4H3,(H,19,20)
Key:KHLJKRBMZVNZOC-UHFFFAOYSA-N
(verify)
Methallenestril (INN Tooltip International Nonproprietary Name ) (brand names Cur-men , Ercostrol , Geklimon , Novestrine , Vallestril ), also known as methallenoestril (BAN Tooltip British Approved Name ) and as methallenestrol , as well as Horeau's acid ,[1] [2] is a synthetic nonsteroidal estrogen and a derivative of allenolic acid and allenestrol (specifically, a methyl ether of it) that was formerly used to treat menstrual issues but is now no longer marketed.[3] [4] [5] [6] It is a seco-analogue of bisdehydrodoisynolic acid , and although methallenestril is potently estrogenic in rats, in humans it is only weakly so in comparison.[7] Vallestril was a brand of methallenestril issued by G. D. Searle & Company in the 1950s.[8] Methallenestril is taken by mouth .[9] By the oral route, a dose of 25 mg methallenestril is approximately equivalent to 1 mg diethylstilbestrol , 4 mg dienestrol , 20 mg hexestrol , 25 mg estrone , 2.5 mg conjugated estrogens , and 0.05 mg ethinylestradiol .[9]