Clinical data | |
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Trade names | Actriol, Arcagynil, Klimadoral |
Other names | Epioestriol; 16β-Epiestriol; 16-Epiestriol; 16β-Hydroxy-17β-estradiol |
Routes of administration | By mouth |
Drug class | Estrogen |
Identifiers | |
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CAS Number | |
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ChemSpider | |
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ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.008.126 |
Chemical and physical data | |
Formula | C18H24O3 |
Molar mass | 288.387 g·mol−1 |
3D model (JSmol) | |
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Epiestriol (INNTooltip International Nonproprietary Name) (brand names Actriol, Arcagynil, Klimadoral), or epioestriol (BANTooltip British Approved Name), also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is a minor and weak endogenous estrogen, and the 16β-epimer of estriol (which is 16α-hydroxy-17β-estradiol).[1][2] Epiestriol is (or has previously been) used clinically in the treatment of acne.[1] In addition to its estrogenic actions, epiestriol has been found to possess significant anti-inflammatory properties without glycogenic activity or immunosuppressive effects, an interesting finding that is in contrast to conventional anti-inflammatory steroids like hydrocortisone (a glucocorticoid).[3][4]
Compound | PRTooltip Progesterone receptor | ARTooltip Androgen receptor | ERTooltip Estrogen receptor | GRTooltip Glucocorticoid receptor | MRTooltip Mineralocorticoid receptor | SHBGTooltip Sex hormone-binding globulin | CBGTooltip Corticosteroid binding globulin | ||
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Estradiol | 2.6 | 7.9 | 100 | 0.6 | 0.13 | 8.7 | <0.1 | ||
Alfatradiol | <1 | <1 | 15 | <1 | <1 | ? | ? | ||
Estriol | <1 | <1 | 15 | <1 | <1 | ? | ? | ||
16β-Epiestriol | <1 | <1 | 20 | <1 | <1 | ? | ? | ||
17α-Epiestriol | <1 | <1 | 31 | <1 | <1 | ? | ? | ||
Values are percentages (%). Reference ligands (100%) were progesterone for the PRTooltip progesterone receptor, testosterone for the ARTooltip androgen receptor, E2 for the ERTooltip estrogen receptor, DEXATooltip dexamethasone for the GRTooltip glucocorticoid receptor, aldosterone for the MRTooltip mineralocorticoid receptor, DHTTooltip dihydrotestosterone for SHBGTooltip sex hormone-binding globulin, and cortisol for CBGTooltip Corticosteroid-binding globulin. |
Antibacterial | |
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Keratolytic | |
Anti-inflammatory | |
Antibiotics | |
Hormonal | |
Retinoids | |
Other | |
Combinations | |
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Estrogens |
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Antiestrogens |
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ERTooltip Estrogen receptor |
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GPERTooltip G protein-coupled estrogen receptor |
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