Koštani gama-karboksiglutamatni (gla) protein

PDB prikaz baziran na 1q8h.

Dostupne strukture

1q3m, 1q8h

Identifikatori

Simboli

BGLAP; BGP; OC

Vanjski ID

OMIM: 112260 MGI: 88156 HomoloGene: 104130 GeneCards: BGLAP Gene

Ontologija gena
Molekularna funkcija	• aktivnost strukturnih molekula • vezivanje jona kalcijuma • strukturni sastojak kostiju • vezivanje hidroksiapatita
Celularna komponenta	• ekstracelularni region • ekstracelularni prostor • grubi endoplazmatični retikulum • Goldžijev aparat • za membranu vezana vezikula • ćelijska projekcija
Biološki proces	• skeletalni sistemski razvoj • osteoblastna diferencijacija • osteoblastni razvoj • ćelijska adhezija • ćelijsko starenje • respons na mehanički stimulus • respons na gravitaciju

Ortolozi

Vrsta

Čovek

Miš

RefSeq (mRNA)

RefSeq (protein)

Lokacija (UCSC)

Chr 1:
156.21 - 156.21 Mb

Chr 3:
88.17 - 88.18 Mb

PubMed pretraga

[1]

[2]

Osteokalcin (koštani protein koji sadrži gama-karboksiglutaminsku kiselinu, BGLAP) je nonkolagenozni protein nađen u kostima i dentinu. Kod ljudi, osteocalcin je kodiran BGLAP genom.^[1]^[2]

Funkcija

Osteokalcin izlučuju isključivo osteoblasti. Smatra se da on ima ulogu u telesnoj metaboličkoj regulaciji i formiranju kostiju.^[3] On je takođe impliciran u koštanu mineralizaciju i homeostazu jona kalcijuma. On deluje kao hormon u telu, koji stimuliše beta ćelije u pankreasu da otpuste više insulina, i istovremeno usmerava ćelije masnoće da otpuštaju hormon adiponektin, koji povećava senzitivnost na insulin.^[3]

Reference

↑ Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). „Chromosomal localization of the human osteocalcin gene”. Endocrinology 124 (5): 2648–50. DOI:10.1210/endo-124-5-2648. PMID 2785029.
↑ Cancela L, Hsieh CL, Francke U, Price PA (September 1990). „Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene”. J. Biol. Chem. 265 (25): 15040–8. PMID 2394711.
↑ ^3,0 ^3,1 Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (August 2007). „Endocrine regulation of energy metabolism by the skeleton”. Cell 130 (3): 456–69. DOI:10.1016/j.cell.2007.05.047. PMC 2013746. PMID 17693256.

Literatura

Kamdem LK, Hamilton L, Cheng C, et al. (2008). „Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia.”. Pharmacogenet. Genomics 18 (6): 507–14. DOI:10.1097/FPC.0b013e3282fc5801. PMID 18496130.
Lin GT, Tseng HF, Chang CK, et al. (2008). „SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.”. Chin J Physiol 51 (1): 32–41. PMID 18551993.
Lumachi F, Camozzi V, Tombolan V, Luisetto G (2009). „Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus.”. Ann. N. Y. Acad. Sci. 1173 Suppl 1: E64-7. DOI:10.1111/j.1749-6632.2009.04955.x. PMID 19751417.
Kanazawa I, Yamaguchi T, Yamamoto M, et al. (2009). „Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes.”. Calcif. Tissue Int. 85 (3): 228–34. DOI:10.1007/s00223-009-9272-4. PMID 19641839.
Makita N, Suzuki M, Asami S, et al. (2008). „Two of four alternatively spliced isoforms of RUNX2 control osteocalcin gene expression in human osteoblast cells.”. Gene 413 (1-2): 8–17. DOI:10.1016/j.gene.2007.12.025. PMID 18321663.
Desbois C, Karsenty G (1995). „Osteocalcin cluster: implications for functional studies.”. J. Cell. Biochem. 57 (3): 379–83. DOI:10.1002/jcb.240570302. PMID 7768973.
Salem AM, Zohny SF, Abd El-Wahab MM, Hamdy R (2007). „Predictive value of osteocalcin and beta-CrossLaps in metastatic breast cancer.”. Clin. Biochem. 40 (16-17): 1201–8. DOI:10.1016/j.clinbiochem.2007.07.006. PMID 17889845.
Im JA, Yu BP, Jeon JY, Kim SH (2008). „Relationship between osteocalcin and glucose metabolism in postmenopausal women.”. Clin. Chim. Acta 396 (1-2): 66–9. DOI:10.1016/j.cca.2008.07.001. PMID 18657532.
Ba Y, Huang H, Yang Y, et al. (2009). „The association between osteocalcin gene polymorphism and dental fluorosis among children exposed to fluoride in People's Republic of China.”. Ecotoxicol. Environ. Saf. 72 (8): 2158–61. DOI:10.1016/j.ecoenv.2009.08.014. PMID 19767102.
Hwang YC, Jeong IK, Ahn KJ, Chung HY (2009). „The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects.”. Diabetes Metab. Res. Rev. 25 (8): 768–72. DOI:10.1002/dmrr.1045. PMID 19877133.
Yerges LM, Klei L, Cauley JA, et al. (2009). „High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.”. J. Bone Miner. Res. 24 (12): 2039–49. DOI:10.1359/jbmr.090524. PMC 2791518. PMID 19453261.
Yu S, Jiang Y, Galson DL, et al. (2008). „General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2.”. J. Biol. Chem. 283 (9): 5542–53. DOI:10.1074/jbc.M705653200. PMID 18171674.
Kayed H, Bekasi S, Keleg S, et al. (2007). „BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion.”. Mol. Cancer 6: 83. DOI:10.1186/1476-4598-6-83. PMID 18163903.
French D, Hamilton LH, Mattano LA, et al. (2008). „A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.”. Blood 111 (9): 4496–9. DOI:10.1182/blood-2007-11-123885. PMID 18285546.
Pittas AG, Harris SS, Eliades M, et al. (2009). „Association between serum osteocalcin and markers of metabolic phenotype.”. J. Clin. Endocrinol. Metab. 94 (3): 827–32. DOI:10.1210/jc.2008-1422. PMID 19088165.
Kindblom JM, Ohlsson C, Ljunggren O, et al. (2009). „Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men.”. J. Bone Miner. Res. 24 (5): 785–91. DOI:10.1359/jbmr.081234. PMID 19063687.
Wahlgren CM, Zheng W, Shaalan W, et al. (2009). „Human carotid plaque calcification and vulnerability. Relationship between degree of plaque calcification, fibrous cap inflammatory gene expression and symptomatology.”. Cerebrovasc. Dis. 27 (2): 193–200. DOI:10.1159/000189204. PMID 19136823.
Lumachi F, Ermani M, Camozzi V, et al. (2009). „Changes of bone formation markers osteocalcin and bone-specific alkaline phosphatase in postmenopausal women with osteoporosis.”. Ann. N. Y. Acad. Sci. 1173 Suppl 1: E60-3. DOI:10.1111/j.1749-6632.2009.04953.x. PMID 19751416.
Born AK, Rottmar M, Lischer S, et al. (2009). „Correlating cell architecture with osteogenesis: first steps towards live single cell monitoring.”. Eur Cell Mater 18: 49–60, 61–2; discussion 60. PMID 19856264.
Fujisawa R (2002). „[Recent advances in research on bone matrix proteins]”. Nippon Rinsho 60 Suppl 3: 72–8. PMID 11979972.

Spoljašnje veze

MeSH Osteocalcin

PDB Galerija

1q3m: 1H NMR strukturni svežanj goveđeg Ca2+-osteokalcina

1q8h: Kristalna struktura svinjskog osteokalcina

Endokrini sistem: hormoni (Peptidni hormoni • Steroidni hormoni)

Endokrine
žlezde

Hipotalamusno-
hipofizni

Hipotalamus	GnRH • TRH • Dopamin • CRH • GHRH/Somatostatin • Melanin-koncentrirajući hormon
Posteriorno hipofizni	Vazopresin • Oksitocin
Anteriorno hipfizni	α (FSH FSHB, LH LHB, TSH TSHB, CGA) • Prolaktin • POMC (CLIP, ACTH, MSH, Endorfini, Lipotropin) • GH