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Chemical and physical data | |
Formula | C19H22N4O2S |
Molar mass | 370.47 g·mol−1 |
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Telenzepine is a thienobenzodiazepine acting as selective M1 antimuscarinic. It is used in the treatment of peptic ulcers.[1] Telenzepine is atropisomeric, in other words the molecule has a stereogenic C–N-axis. In neutral aqueous solution it displays a half-life for racemization of the order of 1000 years. The enantiomers have been resolved. The activity is related to the (+)-isomer which is about 500-fold more active than the (–)-isomer at muscarinic receptors in the rat cerebral cortex.[2]
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Antidepressants (Tricyclic antidepressants (TCAs)) |
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Antihistamines |
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Antipsychotics |
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Anticonvulsants | |
Anticholinergics | |
Others |
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1,4-Benzodiazepines |
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1,5-Benzodiazepines | |
2,3-Benzodiazepines* | |
Triazolobenzodiazepines | |
Imidazobenzodiazepines | |
Oxazolobenzodiazepines | |
Thienodiazepines | |
Thienotriazolodiazepines | |
Thienobenzodiazepines* | |
Pyridodiazepines | |
Pyridotriazolodiazepines | |
Pyrazolodiazepines | |
Pyrrolodiazepines | |
Tetrahydroisoquinobenzodiazepines | |
Pyrrolobenzodiazepines* | |
Benzodiazepine prodrugs | |
* atypical activity profile (not GABAA receptor ligands) |
H2 antagonists ("-tidine") | |
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Prostaglandins (E)/ analogues ("-prost-") | |
Proton-pump inhibitors ("-prazole") | |
Potassium-competitive acid blockers ("-prazan") |
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Others | |
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