This is the talk page for discussing improvements to the Sodium nitroprusside article. This is not a forum for general discussion of the article's subject. |
Article policies
|
Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL |
![]() | Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Sodium nitroprusside.
|
![]() | The contents of the Nitroprusside reaction page were merged into Sodium nitroprusside. For the contribution history and old versions of the redirected page, please see its history; for the discussion at that location, see its talk page. |
![]() | This article is rated Start-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||||||||||||||||||||||
|
This page seems to be focused on the compound's use in medicine, but there seem to be other uses. It is used in the detection of methamphetamine and MDMA and seems to be a common drug-test reagent. If there are enough non-medicinal uses, a new section might help. --24.16.148.75 15:45, 12 July 2006 (UTC)
I agree with the above. The page listed the chemical as non-hazardous, but common MSDS's (which should be pointed at by this page) list hazards identical to cyanide poisoning.
It was also mentioned as a candidate for next-generation optical memory devices. ("Наука и жизнь" mag., www.nkj.ru, few years ago.)As stated in that article, it is normally transparent to red and green light; blue light gradually makes it black (i.e. no longer transparent to red and green), and red light reverses the effect. Please check that!
217.8.94.135 16:22, 7 September 2007 (UTC)
"Its mechanism of action appears to be liberation of nitric oxide (NO), converting Haemoglobin to cyanomethaemaglobin". NO surely works by binding to the haem group of guanylyl cyclase, activating it and so increasing levels of cGMP, ultimately relaxing vascular smooth muscle. NO would be taken up by red cells and would convert some of their haem to methaemoglobin, but that is hardly the mechanism of action.Moletrouser (talk) 15:56, 19 January 2008 (UTC)
It says this is a paramegnetic ion. Off the top of my head, if it's Fe(II) with that ligand set it would be low spin and diamagnetic. Chris (talk) 19:32, 8 August 2008 (UTC)
What's the link between Sodium nitroprusside and Nitroglycerin? In The Netherlands we don't know nitroprusside, only nitroglycerin. PizzaMan (talk) 12:39, 8 July 2009 (UTC)
The -N=O ending in the schematics has too many links (3) between N and O. Should be 2 (N is 3-valent, while O is bivalent).
Could someone please fix the image?
Hmm... there should be three bonds. If there are only two bonds, I would imagine the M-N-O bond would be bent. --Rifleman 82 (talk) 16:43, 30 October 2010 (UTC)
I believe that we should create two pages: one devoted to its medical uses and one to its non-medical uses and chemical properties, partly because I would like to create a drugbox for SNP and seeing how this page isn't just about its medical uses it would be inappropriate for this page. Fuse809 (talk) 23:53, 19 November 2013 (UTC)
I recommended it because this is the size the medical uses section would be if we were to combine the two on the single page. Plus, what's wrong with the image I used? There's nothing wrong with it from what I can tell, in fact it's a more accurate depiction of the compound's structure. Fuse809 (talk) 05:53, 20 November 2013 (UTC)
Nice work putting together the "medication" material together. We don't like to fork articles unnecessarily. Since both articles are of modest length, so a merger will reduce duplication and add breadth and depth to the combined article. Chembox is actually able to show drug and pharma info. I'll help you with that, and I'll incorporate the current "medication" material into the current article, redirect that "article" here, and merge the edit history. We can expand the article here in future. --Rifleman 82 (talk) 03:40, 21 November 2013 (UTC)
As this article is mostly about the medication should have a "drugbox". Please placed it. Doc James (talk · contribs · email) (if I write on your page reply on mine) 05:42, 21 November 2013 (UTC)
Typically follow WP:MEDMOS for meds. Doc James (talk · contribs · email) (if I write on your page reply on mine) 09:31, 22 November 2013 (UTC)
Nice to see that article back together. Nitroprusside is an important coordination complex from a pedagogical perspective. This article is probably one of those cases where two MOS's apply. --Smokefoot (talk) 13:32, 22 November 2013 (UTC)
Thanks to the committed editors of this article. It is happening upon an article generally well done like this, vis-a-vis scope, sourcing, and accuracy, that I retain some hope for Wikipedia STEM articles. Brava/bravo, grazie. Le Prof Leprof 7272 (talk) 13:20, 15 May 2014 (UTC)
… I have to question whether the following paragraph is in the wrong article:
It has nothing to do with the mechanism of action of the title agent (which is already well described in the first paragraph of the section).
If the point is that the article's title therapeutic agent is approved in treatment of these disorders—or even that it is being used off-label in their treatment—this needs to be stated explicitly, and citations provided—without a great deal of further work, one cannot readily see the valid connection between nitroprusside and this paragraph (either via text or citation titles). Even with either of these two positive "takes" on this text, it is inexplicit and far too long, and so undermines and overshadows the point of this section (drug mechanism of action).
Finally, if the suggestion (medical hypothesis) is being offered, that nitroprusside could be used in these disorders ("may also implicate the potential of drugs that alter NO"), then this needs to be stated explicitly, but only with citation. Otherwise it is WP:OR, and has no place. (Either the literature has suggested nitroprusside for these, or it has not, and the titles do not clarify. If not, Wikipedia cannot be the first to mention.)
Apart from the OR and length issues, it is a well-written and referenced paragraph, though; that it does not belong here, does not mean it should not go somewhere (NO and schizophrenia articles?). Le Prof — Preceding unsigned comment added by Leprof 7272 (talk • contribs) 13:48, 15 May 2014 (UTC)
Not mentioned in text. 86.164.23.31 (talk) 23:54, 21 March 2015 (UTC)
"The destruction of disulfide bonds liberates cysteine from cystine and homocysteine from homocystine"
Shouldn't it be: cystathionine (disulfide linked) from homocysteine (broken up)? — Preceding unsigned comment added by 68.112.102.113 (talk) 20:31, 16 May 2015 (UTC)
Recently I had to find something on nitroprusside reaction with amino acids and by chance I had found that there are two separate articles on Wiki. There is this main document on nitroprusside itself and a four sentence long stub, called Nitroprusside reaction only about its reaction with thiol groups of cysteine. I think it would be better to merge those two together.
I would do this myself, but I never did such thing before and I am not shure how many things you have to change in order to do so (disambiguation pages, links from other articles). If somebody has a good guide on how to do this, please share. Thanks.
--Light Code (talk) 18:22, 16 January 2019 (UTC)
In structure and properties oxidation of state of iron is mentioned 3 (above) and 2 (below) respectively. oxidation of state of iron should be made clear with good reference. JAY SWAMINARAYAN 378 (talk) 05:17, 17 August 2021 (UTC)