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Just included some info on n-myc amplification. I believe this can occur in up to 80% of cases so it should be included.Hoganpc (talk) 14:20, 16 April 2012 (UTC)
doi:10.1016/S0140-6736(07)60983-0 - recent Lancet review JFW | T@lk 12:22, 24 June 2007 (UTC)
I'm wondering what people think about creating a new page for discussion of the 3F8 antibody. Space could also be dedicated to discussion of Dr. Cheung's hu3F8. I suppose that a section could be added to this page, instead. Thoughts? MeredithParmer (talk) 07:12, 19 February 2008 (UTC)
Changed "prevention" section to "etiology" and provided some up to date links to peer reviewed journals. Previous link was to a tabloid article that reported a beneficial effect of taking multivitamins, when the study was funded by a (you guessed it!) multivitamin company. Nor did it appear in peer reviewed journal. Apologies for number of separate page edits, but this was my first go. Ironick 10:37, 5 September 2007 (UTC)
"The diagnosis is usually confirmed by a surgical pathologist, taking into account the clinical presentation, microscopic findings, and other laboratory tests. On microscopy, the tumor cells are typically described as small, round and blue, and rosette patterns (Homer-Wright pseudo-rosettes) may be seen. A variety of immunohistochemical stains are used by pathologists to distinguish neuroblastomas from histological mimics, such as rhabdomyosarcoma, Ewing's sarcoma, lymphoma and Wilms' tumor. The N-myc amplification is characteristic, and sometimes electron microscopy is also required."
This contribution of mine was removed without discussion. I am a pathologist but have written it with the intelligent layman in mind. The present reference to neuron-specific enolase is wrong, and the whole paragraph was deleted without discussion. I would find it helpful if people explained their need to remove great slabs of info.
Would fellow users care to comment?
Hovea 22:55, 10 September 2007 (UTC)
Agreed, no idea why that should be excluded. I like the pathological description. I think this section needs work, perhaps even splitting "symptoms" from the diagnosis section, where less technical language can be used. Then this pathological info can be put back into the diagnosis/identification section. I really don't like the "great masquerader" line (unless it can be cited). Let me know your thoughts.
Also the article needs some prevalence and survival data, as an Epidemiologist I will have a look and update this, I think Little 1999 (ISBN 92-832-2149-4) is likely to be the best source. Ironick 10:47, 11 September 2007 (UTC)
Thanks Ironick. I'm with you on this one & I've made a start. Hovea 23:07, 11 September 2007 (UTC)
I just noticed the above quoted material in in the article twice. Where do you think it fits best? DMLudwinski (talk) 16:12, 15 December 2007 (UTC)
I think this section should be changed to reflect the new INRG plan (ref Lancet June 2007 Maris et al). The stages will be called L1, L2, M and MS, and 12-18 month olds without N-myc amplification will be no longer considered high-risk (moved to intermediate risk).
This change in classification with 12-18 month olds (N-myc non-amp) started in the COG May 2004.
This material was also presented at the 2007 ASCO meeting, and virtual presentations are viewable online at ASCO Pediatric Cancers (Neuroblastoma Pediatric Cancer I and Neuroblastoma---Recent Advances in Biology and Therapy Education session) see Dr S Cohn abstract 9503
Thanks for the excellent work on this page! I would personally like to see a LOT more on pathology! DMLudwinski (talk) 23:12, 11 December 2007 (UTC)
(talk) 18:53, 11 December 2007 (UTC)
Arcadian, the image is great (as are other improvements to the article)! I noticed the image added is ganglioneuroblastoma, and checking the NCI link, there is a image of neuroblastoma also, showing the distinctive rosettes. Would that be a better image to include? Or both--since ganglioneuroblastoma is treated similarly to neuroblastoma (depending on the age and stage and risk assignment)? Thanks! I do not know how to add images (I am very slowly getting up to speed for editing, but plan to help here!)
DMLudwinski (talk) 15:48, 16 December 2007 (UTC)
Thanks! I clicked on the image you added, and below the image the description states the source. I went to the cancer.gov source and did a search on neuroblastoma and found a photo of NB: neuroblastoma I think it public domain, but do not know how to add it to the NB article. Thanks for your help! DMLudwinski (talk) 19:35, 19 December 2007 (UTC)
I'll probably read through in detail tomorrow, but a first speed read suggests careful copyediting and checking for readability would be helpful. Just a quick read suggests MoS issues - eg ref numbers should follow punctuation with no space, and there are some places where glosses would help. The very last sentence, which looks odd, starting with a lower-case letter, would be much improved as "The protein p53...". There are places where a gloss for meaning might be helpful, esp if the phrase is a red-link. Jimfbleak (talk) 09:11, 30 December 2007 (UTC)
I'll do the formal review by Friday, please let me know if more time needed. Jimfbleak (talk) 08:11, 1 January 2008 (UTC)
Much work to be done here! Thanks so much.208.123.11.69 (talk) 18:15, 1 January 2008 (UTC)
Thanks for the offer of help with references Arcadian. Below is an accumulation of information on clinical trials with external links. It may be too much and I have no problem with it being greatly simplified or ignored altogether. There is a little more to be said about efforts with anti-GD2 antibodies which I can add later. DMLudwinski (talk) 16:33, 2 January 2008 (UTC)
Currently there is no “standard” frontline treatment for high-risk neuroblastoma because the relapse rate is still unacceptably high. In an effort to improve survival rates for high-risk neuroblastoma, various therapies (clinical trials) are planned and carried out by cooperative groups as well as individual and small groups of institutions. Many patients are needed for phase III (randomized) trials to discern the effectiveness of new therapies. Worldwide incidence of high-risk NB is estimated to be 6,000 to 7,000 annually--compared to only 300-350 in the US-- so cooperative groups are often international.
A short history of phase III studies for high-risk neuroblastoma
Children's Oncology Group (COG) http://www.curesearch.org/resources/cog.aspx is the result of a merger http://jnci.oxfordjournals.org/cgi/content/full/92/23/1876 in 1999 with Children's Cancer Group (CCG) and Pediatric Oncology Group (POG), and currently has over 230 member institutions in the US, Canada, Australia, New Zealand, Netherlands, and Switzerland. COG is the largest pediatric cancer group, and 40,000 http://www.curesearch.org/our_research/index_sub.aspx?id=1523 children and young adults are currently treated on approximately 150 COG protocols. Requirements http://www.childrensoncologygroup.org/MiscellaneousPdf/3.1.1InstMmbrshp.pdf for membership as a COG institution and principal investigator include treating a minimum annual average of twelve newly diagnosed pediatric cancer cases. COG investigators must also enroll a minimum annual average of six children on COG therapeutic trials and a minimum of two children on non-therapeutic trials. Specific support http://www.childrensoncologygroup.org/MiscellaneousPdf/3.1.2ReqInstMmbrshp.pdf specialists and facilities must also be provided in COG institutions. Every pediatric oncology patient treated at COG hospitals must be registered in the COG database, even if they are not treated on a COG protocol.
A group of investigators specializing in neuroblastoma at 13 institutions comprise the New Approaches to Neuroblastoma Therapy http://www.nant.org (NANT) consortium. This group plans and offers phase I and phase II trials for refractory and relapsed neuroblastoma only (no frontline therapies).
The various study groups (COG, GPOH, E-SIOP, etc) each have protocols used to treat each risk group of neuroblastoma. Some COG institutions enroll patients on their own "in-house" trials. These are often called pilot studies, and occasionally include more than one institution. Memorial Sloan Kettering (MSK) http://www.mskcc.org/mskcc/html/62094.cfm , Children's Hospital of Philadelphia (CHOP) http://www.chop.edu/consumer/jsp/division/generic.jsp?id=77780 , Dana-Farber Cancer Institute (DFCI)/Boston Children's http://www.childrenshospital.org/az/Site1084/mainpageS1084P0.html , Chicago's Children's Memorial Hospital (CMH) http://www.childrensmemorial.org/depts/cancer/neuroblastoma1.aspx and St Jude’s http://www.stjude.org/stjude/v/index.jsp?vgnextoid=72df722d99f70110VgnVCM1000001e0215acRCRD&vgnextchannel=85e0bfe82e118010VgnVCM1000000e2015acRCRD are all notable examples of this. The institutional studies are possible because of the relatively large number of neuroblastoma cases they treat.
General rationale for current therapies--resources
Advances in the Diagnosis and Treatment of Neuroblastoma http://theoncologist.alphamedpress.org/cgi/content/full/8/3/278 Joanna L. Weinstein, Howard M. Katzenstein, Susan L. Cohn. The Oncologist, Vol. 8, No. 3, 278–292, June 2003
High-Risk Neuroblastoma: Beyond Intensification to Novel Therapy Approaches to Improve Outcome http://www.ipcr.us/dl/ASCO_ED_Neuroblastoma2005.pdf ASCO 2005 presentation by K. Matthay, CP Reynolds, R Versteeg
Risk-based Treatment for Children with Neuroblastoma http://www.cure4kids.org/private/courses_documents/m_148/DeBernardai_Bruno.pdf SIOP 2005 presentation by Bruno De Bernardi and Susan L. Cohn
Reduction From Seven to Five Cycles of Intensive Induction Chemotherapy in Children With High-Risk Neuroblastoma http://www.jco.org/cgi/content/full/22/24/4888 Brian H. Kushner, Kim Kramer, Michael P. LaQuaglia, Shakeel Modak, Karima Yataghene, Nai-Kong V. Cheung. Journal of Clinical Oncology, Vol 22, No 24 (December 15), 2004: pp. 4888-4892
ASCO 2007 presentations by S. Kreissman, J. Park, NK Cheung, J. Maris Pediatric Cancer I http://www.asco.org/portal/site/ASCO/menuitem.64cfbd0f85cb37b2eda2be0aee37a01d/?vgnextoid=09f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=vm_session_presentations_view&index=y&confID=47&trackID=10&sessionID=394 and Education Session Recent Advances in Biology and Therapy http://www.asco.org/portal/site/ASCO/menuitem.64cfbd0f85cb37b2eda2be0aee37a01d/?vgnextoid=09f8201eb61a7010VgnVCM100000ed730ad1RCRD&vmview=vm_session_presentations_view&index=y&confID=47&trackID=10&sessionID=222
Neuroblastoma http://www.ncbi.nlm.nih.gov/pubmed/17586306?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum John M Maris, Michael D Hogarty, Rochelle Bagatell, Susan L Cohn. Lancet, 369: 2106–20, June 23, 2007
Text reference:
Cheung NK and Cohn SL eds. Neuroblastoma. Springer: Berlin (2005)
DMLudwinski (talk) 16:33, 2 January 2008 (UTC)
DMLudwinski (talk) 18:19, 2 January 2008 (UTC)
Pwallroth asked this question via email:
Any thoughts? Since the other section (clinical trials for frontline therapy) is listed chronologically, I would think that section would also have to be rewritten in reverse chronological order.DMLudwinski (talk) 12:34, 17 June 2008 (UTC)
The Childrens Neuroblastoma Cancer Foundation
There is hope.
http://www.nbhope.org/ —Preceding unsigned comment added by 70.235.188.214 (talk) 20:27, 14 August 2008 (UTC)
Also http://http://www.worldcommunitygrid.org/research/hfcc/overview.do - research that anyone with a PC can help with (and Mac, Linux, etc). Can this link be made part of the full article? There must be people reading the main article who'd love to know how they can help future generations? But I'll leave someone who knows more about Wikipedia than me to decide. —Preceding unsigned comment added by 80.175.12.57 (talk) 10:07, 22 January 2010 (UTC)
The page doesn't explain what is meant by refactory neuroblastoma. I'm not a clinician, and haven't heard this use. If someone could clarify?
I'm not sure whther sections 5.2 and 5.3 should be distinct? Perhaps they could be merged and cut down slightly? Perhaps restrict these sections to current trials rather than a history of neauroblastoma treatment. I think these parts are too long, and perhaps should be referenced for the very interested rather than included on a general page?
Ironick (talk) 09:49, 16 October 2008 (UTC)
I removed 2 lines at the end of the introduction. No objection to reinclusion, but they should be cited. Especially the spontaneous regression part. I definately think the clinical trials for new treatments should be moved to a new page something like "Treatment of Neuroblastoma" and linked to other treatments etc. I also remember there being a history of treatment as well, which could be included there. I think this page should be a detailed introduction, I feel this information is too specific. Thoughts? Ironick (talk) 10:15, 29 April 2009 (UTC)
--Doc James (talk · contribs · email) 20:44, 9 June 2009 (UTC)
Another issue
The incidence rates quoted in the first sentence lack context. The number of cases per year should be given in per capita rather than absolute terms, especially since the statement is made that it is the most common cancer in infancy. 121.45.223.193 (talk) 12:12, 6 December 2013 (UTC)
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The word "baby" in this sentence is obviously not correct: "Occasionally it may be found in a baby by ultrasound during pregnancy." I tried to correct it to "fetus" instead, but got reverted. Someone else may want to fix this. SilverCobweb (talk) 23:18, 10 December 2016 (UTC)
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