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Actually the septal that is infused with alcohol may not be the first septal perforator. What is done in experienced centers is an echocardiogram (I'm not sure if it is a TTE or TEE) at the time of the angiogram. The septal artery is occluded with a balloon and echo contrast (or agitated saline?) is injected distally into the septal perforator. The wall motion is then observed via echo to see if the gradient improves and also to see what portion of the septum will be affected by the ablation. Will have to find a reference or two to add this to the article. Ksheka 14:13, 30 November 2006 (UTC)
Who first identified hypertrophic cardiomyopathy as a disease? —Temporaluser 07:22, 19 March 2008
hi, can anyone tell me what age is the oldest person live till with hcm please — Preceding unsigned comment added by 86.17.231.204 (talk) 10:44, 13 October 2016 (UTC)
Should there not be an etymology for medical terms? At least people are made aware of the origin of the medical terms and what they mean. For example Hypertrophic from the Greek hyper + trophy and cardiomyopathy from the Greek kardia + mus + pathy.....1.120.132.240 (talk) —Preceding undated comment added 07:26, 13 September 2013 (UTC)
doi:10.1016/S0140-6736(16)31321-6
—JFW | T@lk 09:32, 2 December 2016 (UTC)
doi:10.1016/S0140-6736(12)60397-3
—Patrug (talk) 04:55, 30 December 2016 (UTC)
doi:10.1016/j.amjmed.2016.09.015 not all HCM causes septic hypertrophy. A proportion progresses to CCF. JFW | T@lk 21:13, 22 January 2017 (UTC)
An editor has deleted the entire list of notable cases, which has been part of this article for years. The editor has pointed to WP:MEDTRIVIA, but that says that lists of cases may be maintained (or split to a separate list) as long as they are well-sourced, which this list has been, for the most part. I've raised the issue at Wikipedia talk:Manual of Style/Medicine-related articles#"Notable cases" for a disease?--Arxiloxos (talk) 18:16, 23 January 2017 (UTC)
British comedy actor Leonard Rossiter died from hypertrophic cardiomyopathy in 1984 while waiting to go onstage at the Lyric Theatre, London.
After the death of Marc-Vivien Foé of Cameroon during a 2003 FIFA Confederations Cup match, his autopsy revealed hypertrophic cardiomyopathy.[1] Miklós "Miki" Fehér, a Hungarian football player who died during a match on January 25, 2004, also suffered from HCM.[2][3]
The autopsy of actor Corey Haim identified HCM as one of the contributing causes (along with pneumonia and coronary arteriosclerosis) for his death in 2010.[4]
Internet personality Ben Breedlove of Austin, Texas died on December 25, 2011, from HCM at age 18.[5][6]
Andrew Breitbart, a prominent American conservative journalist, died from hypertrophic cardiomyopathy on February 29, 2012, at age 43.[7]
English footballer Mitchell Cole died from HCM on December 1, 2012, after retiring earlier in the year due to the condition.[8]
Other noted athletes believed or suspected to have died from HCM include NFL players Thomas Herrion,[9] Mitch Frerotte,[10] Gaines Adams,[11][12] and Derrick Faison;[13] NBA players Reggie Lewis,[14][15] Jason Collier,[12] and Kevin Duckworth;[16] NHL player Sergei Zholtok;[9] long-distance runner Ryan Shay;[17] Loyola Marymount basketball star Hank Gathers;[18] Loyola Marymount soccer player David Kucera;[19] Western Kentucky University basketball player Danny Rumph;[citation needed] Kansas State football player Anthony Bates;[20] LSU baseball player Wally Pontiff Jr.;[21] Russian ice hockey star Alexei Cherepanov;[22] and American strongman Jesse Marunde.[23]
The Ontario Hockey League's Mickey Renaud Captain's Trophy honors former Windsor Spitfires captain Mickey Renaud, who died of HCM at age 19.[24]
On December 10, 2008, NBA player Cuttino Mobley announced his retirement due to HCM.[25]
The disease also ended the career of former Wake Forest basketball star Robert O'Kelley, after a mandatory ECG in Brazil discovered his condition in 2006.[26]
Current University of Denver assistant hockey coach David Carle was originally recruited to play for the team, but retired from playing after being diagnosed with HCM at the NHL draft combine. He was nonetheless drafted in the 7th round by the Tampa Bay Lightning.
Former Arsenal and Watford goalkeeper Manuel Almunia announced his retirement on August 26, 2014 after being diagnosed with HCM.[27]
Caleb Logan Bratayley, a 13-year old YouTube star, died from undiagnosed hypertrophic cardiomyopathy on October 1, 2015.[28]
References
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Clallam County Prosecuting Attorney Deborah Kelly, who serves as the county coroner, said that the official cause of death remains an enlarged heart and a condition called hypertrophic myocardium, a rare genetic disease that is characterized by a thickening of the heart muscle.
-- Jytdog (talk) 01:27, 24 January 2017 (UTC)
I'd be more inclined to keep the list of people in there if there were only 10 cases per year, such that people suffering from it are rare. But as the intro states, 0.2% incidence per year, thats a lot of people being diagnosed per year. Actually, that languange could be expanded (xx cases per 100,000 per year is a format I think I've encountered), and could be useful viz this discussion. BakerStMD 16:00, 24 January 2017 (UTC)
The following is unsourced or almost entirely unsourced. Moved here per WP:PRESERVE. Per WP:BURDEN, don't restore without finding MEDRS sources, checking the content against them, and citing them.
Individuals with HCM have some degree of left ventricular hypertrophy. Usually this is an asymmetric hypertrophy, involving the inter-ventricular septum, and is known as asymmetric septal hypertrophy.[1] This is in contrast to the concentric hypertrophy seen in aortic stenosis or hypertension. About two-thirds of individuals with HCM have asymmetric septal hypertrophy.
About 25% of individuals with HCM demonstrate an obstruction to the outflow of blood from the left ventricle during rest. In about 70% of patients, however, the obstruction can be provoked under certain conditions. This is known as dynamic outflow obstruction because the degree of obstruction is variable and is dependent on the loading conditions (ventricular filling and arterial blood pressure) and the contractility state of the left ventricle.
Myocardial hypertrophy and extracellular fibrosis predispose to increased left ventricular stiffness, which in concert with compromised cellular energetics and abnormal calcium handling, leads to diastolic dysfunction manifested as dyspnea and exercise intolerance.
The altered structure of the coronary vessels and increased diastolic pressure (reduced blood supply), together with the hypertrophy and the outflow tract obstruction (increased demand), cause myocardial ischemia that is manifested as angina and may be responsible for the triggering of ventricular arrhythmias.
In about 30% of patients, there are abnormal vascular responses and inability to increase systolic blood pressure during exercise. This is attributed to exaggerated cardiac inhibitory reflexes initiated by increased myocardial wall stress and to elevated levels of vasodilating substances (natriuretic peptides).
Aortic stenosis | Hypertrophic cardiomyopathy | |
---|---|---|
Echocardiography | ||
Aortic valve calcification | Common | No |
Dilated ascending aorta | Common | Rare |
Ventricular hypertrophy | Concentric LVH | Asymmetric, often involving the septum |
Physical examination | ||
Murmur of AI | Common | No |
Pulse pressure after PVC | Increased | Decreased |
Valsalva maneuver | Decreased intensity of murmur | Increased intensity of murmur |
Carotid pulsation | Normal or tardus et parvus | Brisk, jerky, or bisferiens pulse (a collapse of the pulse followed by a secondary rise) |
The physical findings of HCM are associated with the dynamic outflow obstruction that is often present with this disease.
Upon auscultation, the heart murmur will sound similar to the murmur of aortic stenosis. However, a murmur due to HCM will increase in intensity with any maneuver that decreases the volume of blood in the left ventricle (such as standing abruptly or the strain phase of a Valsalva maneuver). Administration of amyl nitrite will also accentuate the murmur by decreasing venous return to the heart. Classically, the murmur is also loudest at the left parasternal edge, 4th intercostal space, rather than in the aortic area.
If dynamic outflow obstruction exists, physical examination findings that can be elicited include the pulsus bisferiens and the double apical impulse with each ventricular contraction. These findings, when present, can help differentiate HCM from aortic stenosis. In addition, if the individual has premature ventricular contractions (PVCs), the change in the carotid pulse intensity in the beat after the PVC can help differentiate HCM from aortic stenosis. In individuals with HCM, the pulse pressure will decrease in the beat after the PVC (Brockenbrough–Braunwald–Morrow sign), while in aortic stenosis, the pulse pressure will increase. However, post-PVC left ventricular systolic pressure and murmur intensity increase in both aortic stenosis as well as HCM.
References
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-- Jytdog (talk) 06:09, 19 October 2017 (UTC)
Too much of this is written as advice to doctors, telling them how to treat patients. This needs to be revised per MEDMOS, addressed to everybody. Jytdog (talk) 01:12, 23 October 2017 (UTC)
Feline hypertrophic cardiomyopathy - do you have plans for this part of the page?Sofia Hanås (SLU) (talk) 14:05, 15 May 2020 (UTC)
Can this condition be caused by external causes, such as drugs, chemicals, poisons, and also infections like bacteria, viruses, etc...?107.195.106.201 (talk) 18:40, 15 April 2022 (UTC)
doi:10.1016/j.jacc.2021.11.021 JFW | T@lk 12:35, 26 January 2023 (UTC)
hocm 163.182.28.136 (talk) 11:55, 5 June 2023 (UTC)