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This does not belong in the category of photographic chemicals. Nowhere in the article does it mention photography, or its use in film making, or any other sort of chemical relation to photography in any way, shape or form. I'm removing it from this category as per the reason I just gave. Cernen Xanthine Katrena 10:40, 23 January 2006 (UTC)
Is glycine a zwitterion? If so, then there is incongruity as glycine states that it is non-polar, but zwitterion suggests that it is polar. Anyone know? Ydnagaj 20:29, 6 February 2007 (UTC)
While free amino acids are Zwitterions, a glycine residue in a peptide has no charge. Biochemists typically are studying the glycine residue in proteins. Clasifying R-groups of amino acids by properties is useful for memorizing and learning, but not completely accurate. For example, Tyr is typically classed as nonpolar, but it has hydroxyl group as well. Glycine, lacking any R group, doesn't really fit into a classification. The polar, uncharged group works best for Gly since side chains in this group do not participate in ionic or hydrogen bonding interactions, which is true for Gly. Qchristensen (talk) 02:59, 2 November 2008 (UTC)
1. I am not a chemist.
2. I am confused: ...
I have not made any edits, these are just thoughts. I leave that for the chemists.
3. Overall, the article is an interesting read ranging from the neurochemical function in the brain to the possible astrochemical occurence in space.
4. At least one of my four comments is useless.
In response to 2: I agree, the first point makes no sense. Changing the last glycine to serine does. Optical activity results from chirality, so it would be more to the point to state that glycine is not chiral, unlike all the other biological amino acids. Qchristensen (talk) 03:06, 2 November 2008 (UTC)
In the section "Presence in the interstellar medium" the statement is made that if glycine is found in the interstellar medium, then "[This] finding would indirectly support the idea of panspermia, the theory that life was brought to Earth from space." For this assertion to be logically consistent one must presuppose that this glycine was produced by, or was the progenitor of, a living entity which predates life on Earth which was then brought to Earth. No evidence has been cited to support these predicates.
I am removing the logically inconsistent statements from the article. Mtiffany71 01:30, 29 June 2007 (UTC)
Tagged for these reasons:
-- B.D.Mills (T, C) 01:25, 24 June 2008 (UTC)
I'm removing the tag - it seems an overreaction. The problem (if any) is minor, not systemic to this article. --Rifleman 82 (talk) 03:56, 24 June 2008 (UTC)
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I've just updated the 3D images of glycine with data from the crystal structure: CrystEngComm (2008) 10, 335-343.
I know that the tradition on Wikipedia is to depict amino acids as uncharged species, not zwitterions, but there is a problem: glycine only exists as a cation, a zwitterion, or an anion (except in the gas phase). I can't get a crystal structure of non-zwitterionic glycine because there isn't one. So for consistency between images in the chembox, I think we must should draw glycine as a zwitterion alongside the neutral form.
There's also the issue of how to depict carboxylate ions:
A section on the structure and protonation states of amino acids is necessary (does one already exist) and it would be good to create a tailor made discussion for each of the the 20 amino acids, with the pKa values and acid-base behaviour of the amino acid in question discussed.
As a start, I've made a diagram:
Ben (talk) 04:41, 17 March 2009 (UTC)
References for the structure of glycine:
Ben (talk) 20:13, 17 March 2009 (UTC)
---
Hello, I disagree with you. This is true of any amino acid but the drawing of the molecule this way is not only confusing to people not as adept in chemistry, but also is not standard. H2CO3 (carbonic acid) also doesn't exist in the form we commonly think of because it isn't at all stable. Yet we still draw it that way, just like we draw the other amino acids normally - because on paper it makes much more sense. I'm not saying you're wrong, I just don't think it should be put on the wiki in that manner.
However, since your argument is strong, I will try to compromise by putting in both the original structure AND the zwitterion. If you want to write a bit about why the molecule is depicted that way (assuming it's not already there) you may.
Qbmaster (talk) 01:54, 28 April 2009
Thanks for your comments, Smoke. I think "this is true of any amino acid" is about the existence of zwitterions in solid and liquid, but neutral in the gas.
The carboxylates issue troubles me a little. The delocalised description is too complicated for a general audience, but the localised description could be misleading - we could go localised and just hope that anyone who cares about the detail will read about carboxylate resonance elsewhere - or we could go localised for the most part, but add a note and link to carboxylate.
Ben (talk) 12:55, 28 April 2009 (UTC)
Dear Manager In the Picture (Molecular Show) of Glycine you show the Blue Nitrogen in wrong form because Nitrogen has a three capacity and after connection to Carbon must be Has two Hydrogen but you show this nitrogen Connected to Carbon and has one Hydrogen excess. Please Check this subject and informed me by email. Best regards Arash Goshtasbi Asl Senior researcher of Petrochemical Engineering from Iran ArashGoshtasbi
--Smokefoot (talk) 04:42, 15 August 2009 (UTC)
Are you sure Gly has two H as its 'side chain'? I think every alpha-aminoacid has an alpha-C bound to four groups or atoms: COOH, NH2, H and side chain. This H, present in every alpha-aminoacid, is not a part of the side chain. So, if I'm not wrong, Gly has one H side chain. Miguelferig (talk) 20:29, 9 July 2011 (UTC)
The GEO web site was added as a reference and as an external link. Looking at the web site, it only indicates that they supply glycine, not how they supply it, therefore its inclusion as reference 9 is flawed. The inclusion of the web site in the External Links is strictly spam. Both need to be removed. I have removed them once and was reverted. WP:COI perhaps?JSR (talk) 16:01, 4 October 2012 (UTC)
I've removed this structure for various reasons.
It is very dispiriting to see comments (above) that the delocalized structure might be too difficult. For whom? The fact is that in the zwitterionic form the two C-O bonds are identical in length etc. This is independent of any particular bonding theory. Therefore it is not satisfactory to show a structure with one single bond and one double bond. At the very least, in valence bond theory, the two canonical forms should be shown as being in resonance. Personally I prefer the dotted line shown in the info box.
The nature of glycine in aqueous solution is that there is an equilibrium between the two forms, with the zwitter ion predominating. The ratio of concentrations of the two microspecies is independent of the glyine concentration and of pH; it's simply the equilibrium constant for isomerization. Petergans (talk) 18:02, 15 September 2013 (UTC)
Role of Glycine in human nutrition The article needs to state whether glycine is or is not an essential amino acid, and what that means.75.164.86.109 (talk) 17:25, 20 March 2014 (UTC)TheNovelist
Should the biosynthesis section not mention something about glycine's synthesis from threonine?
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Wikipedia now says: "Certain drug formulations include glycine to improve gastric absorption of the drug.[25]"
The link 25 is broken. Can you find more information of this?
Also it would be nice to learn more about this buffering:
"Glycine serves as a buffering agent in antacids, analgesics, antiperspirants, cosmetics, and toiletries".
"It serves as a buffering agent, maintaining pH". 91.155.24.127 (talk) 07:15, 20 September 2017 (UTC)
I confuse Glycine with Glycerol Speed57 (talk) 16:18, 21 February 2018 (UTC)
I dont understand how is there only 1 hydrogen atom but there are 2 atoms not in the structure. Can someone tell me how is this possible? Muonium777 (talk) 06:30, 2 November 2021 (UTC)
Reba16 proposes that Glycine hydrochloride be merged into Glycine. Reba16, to start the discussion please describe why you think the articles should be merged. Mdewman6 (talk) 00:30, 3 November 2021 (UTC)
The discussion was initiated at Talk:Glycine_hydrochloride#Merge suggestion where Reba16 writes:
–Mdewman6 (talk) 06:43, 3 November 2021 (UTC)
Pyrolysis of glycine or glycylglycine gives 2,5-diketopiperazine, the cyclic diamide
Pyrolysis usually includes a breakage of C-C bonds. This is simply a second condensation step. --46.232.229.52 (talk) 14:40, 28 February 2022 (UTC)
sulfamic acid is simpler 59.102.93.132 (talk) 01:00, 30 March 2022 (UTC)
Why Ghycine Attach With Carboxyl Acid and Amino Acid 182.189.213.48 (talk) 16:08, 9 June 2022 (UTC)
I have added content to Glycine#As_a_toxin_conjugation_agent. Please review and check it for grammar. Also I wanted to add the following:
Wide uncontrolled use of benzoates as food preservatives has raised healthcare concerns.[1] Researcher hypothesized that depletion of the body glycine supply during benzoates exposure may interfere other biological roles of glycine[2] or peculiarities of the metabolic pathway itself that depend on the type of toxic organic acids, may influence liver cancer, musculoskeletal development, and mitochondrial energy metabolism[3]
But I hesitate in references quality. Tosha Langue (talk) 14:51, 27 January 2024 (UTC)