Ser/Thr protein kinase, TGFB receptor | |
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Identifiers | |
Symbol | TGFb_receptor |
InterPro | IPR000333 |
SCOP2 | 1B6C / SCOPe / SUPFAM |
Membranome | 1216 |
The transforming growth factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors bind growth factor and cytokine signaling proteins in the TGF-beta family such as TGFβs (TGFβ1, TGFβ2, TGFβ3), bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activin and inhibin, myostatin, anti-Müllerian hormone (AMH), and NODAL.[1]
TGFβ family receptors are grouped into three types, type I, type II, and type III. There are seven type I receptors, termed the activin-like receptors (ALK1–7), five type II receptors, and one type III receptor, for a total of 13 TGFβ superfamily receptors.[2][3] In the transduction pathway, ligand-bound type II receptors activate type I receptors by phosphorylation, which then autophosphorylate and bind SMAD.[4] The Type I receptors have a glycine-serine (GS, or TTSGSGSG) repeat motif of around 30 AA, a target of type II activity. At least three, and perhaps four to five of the serines and threonines in the GS domain, must be phosphorylated to fully activate TbetaR-1.[5]
Transforming growth factor beta type I GS-motif | |||||||||
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Identifiers | |||||||||
Symbol | TGF_beta_GS | ||||||||
Pfam | PF08515 | ||||||||
InterPro | IPR003605 | ||||||||
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Unlike the Type I and II receptors which are kinases, TGFBR3 has a Zona pellucida-like domain. Its core domain binds TGF-beta family ligands and its heparan sulfate chains bind bFGF. It acts as a reservoir of ligand for TGF-beta receptors.[6][7]
TGF beta superfamily of ligands |
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TGF beta receptors (Activin, BMP, family) |
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Transducers/SMAD | |||||||
Ligand inhibitors | |||||||
Coreceptors | |||||||
Other |
Type I cytokine receptor | |||||||||||||
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Receptor protein serine/threonine kinase | |||||||||||||
Receptor tyrosine kinase |
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Tumor necrosis factor receptor | |||||||||||||
Ig superfamily | |||||||||||||
Other/ungrouped |
Chemokine receptor (GPCRs) |
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TNF receptor |
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JAK-STAT |
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Ig superfamily | |||||||||||||||
IL 17 family | |||||||||||||||
Enzyme-linked receptor |
Receptor protein serine/threonine kinase | |||||||||||||||||||||||||||||||||||||||||
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Receptor tyrosine kinase |
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Guanylate cyclase-coupled receptor | |||||||||||||||||||||||||||||||||||||||||
Receptor tyrosine phosphatase |
Type I |
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Type II |
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Type III |
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Unsorted |
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