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Routes of administration | PO |
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Chemical and physical data | |
Formula | C22H19N5O |
Molar mass | 369.428 g·mol−1 |
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Galunisertib (LY2157299) is a small molecular experimental cancer drug previously in development by Eli Lilly. It is a TGF-b inhibitor.[1] Development of galunisertib by Eli Lilly was discontinued in January 2020.[2]
Galunisertib was investigated in a phase II trial for treatment of hepatocellular carcinoma.[3] Pre-clinically, combination of galunisertib with PD-L1 blockade resulted in improved tumor growth inhibition.[4]