mir-24 microRNA precursor family | |
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![]() Predicted secondary structure and sequence conservation of mir-24 | |
Identifiers | |
Symbol | mir-24 |
Rfam | RF00178 |
miRBase | MI0000080 |
miRBase family | MIPF0000041 |
Other data | |
RNA type | Gene; miRNA |
Domain(s) | Eukaryota |
GO | GO:0035195 GO:0035068 |
SO | SO:0001244 |
PDB structures | PDBe |
The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19.[1] Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation [2] and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.[3]