In 2016, there were 30 new This American Life episodes.^[1]

• Episode 577 – "Something Only I Can See"
  • air date: 2016-01-15
• Episode 578 – "I Thought I Knew You"
  • air date: 2016-01-29
• Episode 579 – "My Damn Mind"
  • air date: 2016-02-12
• Episode 580 – "That's One Way to Do It"
  • air date: 2016-02-19
• Episode 581 – "Anatomy of Doubt"
  • air date: 2016-02-26
• Episode 582 – "When the Beasts Come Marching In"
  • air date: 2016-03-11
• Episode 583 – "It'll Make Sense When You're Older"
  • air date: 2016-03-25
• Episode 584 – "For Your Reconsideration"
  • air date: 2016-04-08
• Episode 585 – "In Defense of Ignorance"
  • air date: 2016-04-22
• Episode 586 – "Who Do We Think We Are?"
  • air date: 2016-05-06
• Episode 587 – "The Perils of Intimacy"
  • air date: 2016-05-27
• Episode 588 – "Mind Games 2016"
  • air date: 2016-06-03
• Episode 589 – "Tell Me I'm Fat"
  • air date: 2016-06-17
• Episode 590 – "Choosing Wrong"
  • air date: 2016-06-24
• Episode 591 – "Get Your Money's Worth"
  • air date: 2016-07-15
• Episode 592 – "Are We There Yet?"
  • air date: 2016-07-29
• Episode 593 – "Don't Have to Live Like a Refugee"
  • air date: 2016-08-05
• Episode 594 – "My Summer Self"
  • air date: 2016-08-12
• Episode 595 – "Deep End of the Pool"
  • air date: 2016-08-26
• Episode 596 – "Becoming a Badger"
  • air date: 2016-09-09
• Episode 597 – "One Last Thing Before I Go"
  • air date: 2016-09-23
• Episode 598 – "My Undesirable Talent"
  • air date: 2016-10-07
• Episode 599 – "Seriously?"
  • air date: 2016-10-21
• Episode 600 – "Will I Know Anyone at This Party?"
  • air date: 2016-10-28
• Episode 601 – "Master of Her Domain... Name"
  • air date: 2016-11-04
• Episode 602 – "The Sun Comes Up"
  • air date: 2016-11-11
• Episode 603 – "Once More, With Feeling"
  • air date: 2016-12-02
• Episode 604 – "20 Years Later"
  • air date: 2016-12-09
• Episode 605 – "Kid Logic 2016"
  • air date: 2016-12-16
• Episode 606 – "Just What I Wanted"
  • air date: 2016-12-23