In 2013, there were 32 new This American Life episodes.
- Episode 483 – "Self-Improvement Kick"
- Act 1: Is That a Compass, a Map, a Toothbrush, and a Bottle of Purell in Your Pocket, or Are You Just Happy to See Me?
- Act 2: Some Like It Dot
- Episode 484 – " Doppelgangers"
- Act 1: Dead Ringer
- Act 2: In Country, in City
- Episode 485 – "Surrogates"
- Act 1: Petticoats in a Twist
- Act 2: Maul in the Family
- Episode 486 – "Valentine's Day"
- Act 1: Best Laid Plans
- Act 2: 21 Chump Street
- Act 3: Cold Stone Dreamery
- Act 4: My Girlfriend's Boyfriend
- Episode 487 – "Harper High School, Part One"
- Act 1: Rules to Live By
- Act 2: A Tiny Office on the Second Floor
- Act 3: Game Day
- Episode 488 – "Harper High School, Part Two"
- Act 1: The Eyewitness
- Act 2: Your Name Written on Me
- Act 3: Get Your Own Gun
- Act 4: Devonte, Part Two
- Act 5: Reverse Turnaround Backflip
- Episode 489 – "No Coincidence, No Story!"
- Act 1: Grandmas
- Act 2: In God We Trust
- Act 3: Brother, Can You Spare a Dime?
- Act 4: Act Four
- Act 5: What Are the Chances?
- Episode 490 – "Trends with Benefits"
- Act 1: Act One
- Act 2: Act Two
- Episode 491 – "Tribes"
- Act 1: I Know I Am But What Are You?
- Act 2: A Tribe Called Rest
- Act 3: I Am Curious Yellow
- Episode 492 – "Dr. Gilmer and Mr. Hyde"
- Act 1: Act One
- Act 2: Act Two
- Episode 493 – "Picture Show"
- Act 1: Photo Op
- Act 2: A Picture Is Worth a Thousand... Dollars
- Episode 494 – "Hit the Road"
- Act 1: The Slowest Distance Between Two Points
- Act 2: Car Pool
- Act 3: Let's See How Fast This Baby Will Go
- Episode 495 – "Hot in My Backyard"
- Act 1: The CO2 in CO
- Act 2: The Right Man for the Job
- Act 3: Find an Enemy
- Episode 496 – "When Patents Attack... Part Two!"
- Episode 497 – "This Week"
- Act 1: Act One
- Act 2: Act Two
- Act 3: Act Three
- Act 4: Act Four
- Act 5: Act Five
- Act 6: Act Six
- Act 7: Act Seven
- Episode 498 – "The One Thing You're Not Supposed To Do"
- Act 1: Breaking the Ice
- Act 2: The Gun Thing You're Not Supposed to Do
- Act 3: Out of the Woods
- Episode 499 – "Taking Names"
- Act 1: Reluctant Sailor
- Act 2: Emails from a Dead Man
- Episode 500 – "500!"
- A special retrospective episode featuring the producers' favorite segments from the previous 499 episodes.
- Act 1:
- #107, "Trail of Tears"
- #220, "Testosterone"
- #296, "After the Flood"
- #232, "The Real Story"
- #266, "I'm From the Private Sector and I'm Here to Help"
- #334, "Duty Calls"
- #314, "It's Never Over"
- Act 2:
- #27, "The Cruelty of Children"
- #188, "Kid Logic"
- #94, "How To"
- #241, "20 Acts in 60 Minutes"
- Episode 501 – "The View From In Here"
- Act 1: Weeds of Discontent
- Act 2: The Real Housewife of Ciudad Juarez
- Act 3: Movin On Up
- Episode 502 – "This Call May Be Recorded... To Save Your Life"
- Act 1: Act One
- Act 2: Act Two
- Episode 503 – "I Was Just Trying To Help"
- Act 1: Money for Nothing and Your Cows for Free
- Act 2: Nipped in the Bud
- Episode 504 – "How I Got Into College"
- Act 1: The Old College Try
- Act 2: My Ames Is True
- Episode 505 – "Use Only As Directed"
- Act 1: Act 1
- Act 2: Act 2
- Episode 506 – "Secret Identity"
- Act 1: You Can't Handle The Truth
- Act 2: Tiger, Tiger, Burning Bright
- Act 3: The Blonde Avenger
- Episode 507 – "Confessions"
- Act 1: Kim Possible
- Act 2: You Don't Say
- Episode 508 – "Superpowers 2013"
- Act 1: Invisible Man Vs. Hawkman
- Act 2: Wonder Woman
- Act 3: The Green Team Of Boy Millionaires, Beppo The Amazing Supermonkey From Planet Krypton, And The Man From Sram
- Act 4: Villain And Able
- Episode 509 – "It Says So Right Here"
- Act 1: Doe-ppelgangers
- Act 2: What Are You Doing For The Test Of Your Life?
- Act 3: There's A Signed Line Between Love And Hate
- Episode 510 – "Fiasco! 2013"
- Act 1: Opening Night
- Act 2: What We Wanted To Do
- Act 3: Squirrel Cop
- Act 4: Fiascos As A Force For Good In The World
- Episode 511 – "The Seven Things You're Not Supposed To Talk About"
- Act 1: Period
- Act 2: Diet
- Act 3: Health
- Act 4: Sleep
- Act 5: Dream
- Act 6: Route Talk
- Episode 512 – "House Rules"
- Act 1: Rental Gymnastics
- Act 2: The Missionary
- Episode 513 – "129 Cars"
- Act 1: Act 1
- Act 2: Act 2
- Act 3: Act 3
- Act 4: Act 4
- Act 5: Act 5
- Act 6: Act 6
- Act 7: Act 7
- Act 8: Act 8
- Act 9: Act 9
- Act 10: Act 10
- Episode 514 – "Thought That Counts"
- Act 1: Replacement Claus
- Act 2: It's Your Junk In A Box
- Act 3: Christmas Or Bust
