Chemical compound
1V-LSD Routes of administration oral Legal status
In general legal for recreational use, illegal in Sweden and South Korea.
(6aR ,9R )-N ,N -Diethyl-7-methyl-4-pentanoyl-4,,6,6a,7,8,9-hexahydroindolo[4,3-fg ]quinoline-9-carboxamide
PubChem CID UNII CompTox Dashboard (EPA ) Formula C 25 H 33 N 3 O 2 Molar mass 407.558 g·mol−1 3D model (JSmol )
CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)CCCC)c4cccc2c34)N(C)C5
InChI=1S/C25H33N3O2/c1-5-8-12-23(29)28-16-17-14-22-20(19-10-9-11-21(28)24(17)19)13-18(15-26(22)4)25(30)27(6-2)7-3/h9-11,13,16,18,22H,5-8,12,14-15H2,1-4H3/t18-,22-/m1/s1
Key:GIIBVGJWUZNECE-XMSQKQJNSA-N
1V-LSD (1-valeryl-D -lysergic acid diethylamide ), sometimes nicknamed Valerie , is a psychotropic substance and a research chemical with psychedelic effects.[1] [2] 1V-LSD is an artificial derivative of natural lysergic acid , which occurs in ergot alkaloids , as well as being an analogue of LSD .[3]
1V-LSD has been sold online until an amendment to the German NpSG was enforced in 2022 which controls 1P-LSD and now 1cP-LSD , 1V-LSD and several other lysergamides .[4]
Pharmacology As demonstrated with other N-acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act as a weak partial agonist at the 5-HT2A receptor .[3]
Animal studies A Head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD , with behavioral effects also closely resembling these structural analogs .[5]
Chemistry 1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.[6]
Ehrlich's reagent is used to identify the presence of an indole moiety ; the chemical backbone of the lysergamide and ergoline molecules.[7] However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.[8] [9]
Legal position 1V-LSD is illegal in the United States as a Schedule 1 controlled drug or controlled substance under the Federal Analogue Act except if is sold for research and medical purposes like a research chemical. [citation needed ]
Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.
1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.[10]
An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.[11] The law was amended in March 2023, now banning 1V-LSD.
1v-LSD strip blotters
See also
References
^ "1V-LSD (solution)" . www.caymanchem.com .
^ "1V-LSD PsychonautWiki" . Psychonautwiki .
^ a b Brandt SD, Kavanagh PV, Westphal F, Pulver B, Morton K, Stratford A, et al. (November 2021). "Return of the lysergamides. Part VII: Analytical and behavioural characterization of 1-valeroyl-d-lysergic acid diethylamide (1V-LSD)" . Drug Testing and Analysis . 14 (4): 733–740. doi :10.1002/dta.3205 . PMC 9191648 . PMID 34837347 .
^ "1V-LSD - legales LSD 3.0" . YouTube (in German).
^ Halberstadt AL, Chatha M, Klein AK, McCorvy JD, Meyer MR, Wagmann L, Stratford A, Brandt SD (August 2020). "Pharmacological and biotransformation studies of 1-acyl-substituted derivatives of d-lysergic acid diethylamide (LSD)" . Neuropharmacology . 172 : 107856. doi :10.1016/j.neuropharm.2019.107856 . PMC 9191647 . PMID 31756337 .
^ Umehara A, Ueda H, Tokuyama H (November 2016). "Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O". The Journal of Organic Chemistry . 81 (22): 11444–11453. doi :10.1021/acs.joc.6b02097 . PMID 27767302 .
^ De Faubert Maunder MJ (August 1974). "A field test for hallucinogens: further improvements". The Journal of Pharmacy and Pharmacology . 26 (8): 637–8. doi :10.1111/j.2042-7158.1974.tb10677.x . PMID 4155730 . S2CID 97915487 .
^ "REACTIONS 1V-LSD" . 16 July 2021.
^ "1V-LSD reaction with the ehrlich reagent" . 16 July 2021.
^ Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily. Korea Biomedical Review , 5 July 2022
^ "Gesetzespanne: Gefährliche LSD-Derivate plötzlich legal" .
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