CXCL10 |
---|
|
|
識別號 |
---|
别名 | CXCL10;, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10 |
---|
外部ID | OMIM:147310 MGI:1352450 HomoloGene:1203 GeneCards:CXCL10 |
---|
|
|
RNA表达模式 |
---|
|
查阅更多表达数据 |
|
直系同源 |
---|
物種 | 人類 | 小鼠 |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
mRNA序列 | | |
---|
蛋白序列 | | |
---|
基因位置(UCSC) | Chr 4: 76.02 – 76.02 Mb | Chr 5: 92.49 – 92.5 Mb |
---|
PubMed查找 | [3] | [4] |
---|
維基數據 |
|
CXCL10(英語:C-X-C motif chemokine 10)是一小分子的细胞因子属于CXC趋化因子家族[5],又被称作“干扰素伽玛诱导的10千道尔顿蛋白”(10 kDa interferon-gamma-induced protein,IP-10)[6] 。干扰素伽玛可以在多种细胞(如巨噬细胞[7] ,单核细胞[7] ,内皮细胞[8]和成纤维细胞)中诱导CXCL10的表达。CXCL10的功能包括对T细胞和单核细胞的细胞趋化作用[9][10],促进T细胞黏附于内皮细胞[8],抗肿瘤[11],及血管新生[8]。人类的CXCL10基因与CXCL9,CXCL11的基因相邻聚集在第四染色体上。CXCL10, CXCL9和CXCL11结合趋化因子受体CXCR3而起其细胞趋化作用[9][10] 。
- ^ 1.0 1.1 1.2 GRCh38: Ensembl release 89: ENSG00000169245 - Ensembl, May 2017
- ^ 2.0 2.1 2.2 GRCm38: Ensembl release 89: ENSMUSG00000034855 - Ensembl, May 2017
- ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Liu L, Callahan MK, Huang D, Ransohoff RM. Chemokine receptor CXCR3: an unexpected enigma. Curr Top Dev Biol. 2005;68:149-81.
- ^ Kaplan G, Luster AD, Hancock G, Cohn ZA. The expression of a gamma interferon-induced protein (IP-10) in delayed immune responses in human skin. J Exp Med. 1987 Oct 1;166(4):1098-108.
- ^ 7.0 7.1 Narumi S, Hamilton TA. Inducible expression of murine IP-10 mRNA varies with the state of macrophage inflammatory activity. J Immunol. 1991 May 1;146(9):3038-44.
- ^ 8.0 8.1 8.2 Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, Kleinman HK, Reaman GH, Tosato G. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 1;182(1):155-62.
- ^ 9.0 9.1 Loetscher M, Gerber B, Loetscher P, Jones SA, Piali L, Clark-Lewis I, Baggiolini M, Moser B. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 1996 Sep 1;184(3):963-9.
- ^ 10.0 10.1 Weng Y, Siciliano SJ, Waldburger KE, Sirotina-Meisher A, Staruch MJ, Daugherty BL, Gould SL, Springer MS, DeMartino JA. Binding and functional properties of recombinant and endogenous CXCR3 chemokine receptors. J Biol Chem. 1998 Jul 17;273(29):18288-91.
- ^ Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1;178(3):1057-65
|
---|
| 按族分类 | 趋化因子 | CCL |
- CCL1
- CCL2/MCP-1
- CCL3/MIP-1α
- CCL4/MIP-1β
- CCL5/RANTES
- CCL6
- CCL7
- CCL8
- CCL9
- CCL11
- CCL12
- CCL13
- CCL14
- CCL15
- CCL16
- CCL17
- CCL18
- CCL19
- CCL20
- CCL21
- CCL22
- CCL23
- CCL24
- CCL25
- CCL26
- CCL27
- CCL28
|
---|
| CXCL | |
---|
| CX3CL | |
---|
| XCL | |
---|
|
---|
| 肿瘤坏死因子 (TNF)超家族
|
- 肿瘤坏死因子
- 淋巴毒素
- TNFSF4
- TNFSF5/CD40LG
- TNFSF6
- TNFSF7
- TNFSF8
- TNFSF9
- TNFSF10
- TNFSF11
- TNFSF13
- TNFSF13B
- EDA
|
---|
| 白细胞介素 (IL) | 受体为 I型细胞因子受体 | 受体共用β链 |
- IL2/IL15
- IL4/IL13
- IL7
- IL9
- IL21
|
---|
| 受体共用γ链 | |
---|
| IL-6家族/CD130 | |
---|
| IL-12家族/IL12RB1 | |
---|
| 其它 | |
---|
|
---|
| 受体为 II型细胞因子受体 | IL-10家族 |
- IL10/IL22
- IL19
- IL20
- IL24
- IL26
- III型干扰素
|
---|
| 干扰素 (IFN) | I型 |
- Interferon, alpha 1
- IFNA2
- IFNA4
- IFNA5
- IFNA6
- IFNA7
- IFNA8
- IFNA10
- IFNA13
- IFNA14
- IFNA16
- IFNA17
- IFNA21
- IFNB1
- IFNK
- IFNW1
|
---|
| II型 | |
---|
|
---|
|
---|
| 免疫球蛋白超家族 |
- IL-1家族:IL1A
- IL1B
- Interleukin 1 receptor antagonist
- IL1F5
- IL1F6
- IL1F7
- IL1F8
- IL1F9
- IL1F10
- Interleukin 33
- Interleukin 18
|
---|
| IL-17家族 |
- IL17A
- IL17B
- IL17C
- IL17D
- IL17E/IL-25
- IL17F
|
---|
|
---|
| 其它 | |
---|
|
---|
| 按临床 功能分类 | |
---|
| |
|