| Diskoidin domen receptor familija, izoforma 2 | |||
|---|---|---|---|
| Identifikatori | |||
| Simboli | DDR2; MIG20a; NTRKR3; TKT; TYRO10 | ||
| Vanjski ID | OMIM: 191311 MGI: 1345277 HomoloGene: 68505 GeneCards: DDR2 Gene | ||
| Pregled RNK izražavanja | |||
 | |||
| podaci | |||
| Ortolozi | |||
| Vrsta | Čovek | Miš | |
| Entrez | 4921 | 18214 | |
| Ensembl | ENSG00000162733 | ENSMUSG00000026674 | |
| UniProt | Q16832 | Q62371 | |
| RefSeq (mRNA) | NM_001014796 | NM_022563 | |
| RefSeq (protein) | NP_001014796 | NP_072075 | |
| Lokacija (UCSC) |
Chr 1: 160.87 - 161.02 Mb |
Chr 1: 171.81 - 171.95 Mb | |
| PubMed pretraga | [1] | [2] | |
DDR2, ili CD167b (klaster diferencijacije 167b), je ljudski gen[1], koji je član broj 2 familije diskoidin domen receptora.
Receptor tirozin kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su vezani za regulaciju ćelijskog rasta, diferencijacije i metabolizma. U više slučajeva biohemijski mehanizam kojim RTK sprovodi signal kroz membranu je pokazan da se sastoji od ligand indukovane oligomerizacije receptora, i naknadne intracelularna fosforilacije. Ova autofosforilacija dovodi do naknadne fosforilacije citosolnih proteina, kao i do asocijacije sa drugim molekulima koji su vezani za pleiotropske efekte transdukcije signala. RTK proteini imaju trojnu strukturu koja se sastoji od ekstracelularnog, transmembranskog, i citoplazmatičnog regiona. Ovaj gen kodira pripadnika nove RTK podklase sa različitim ekstracelularnim regionom koji okružuje domen sličan faktoru VIII. Alternativno spajanje (engl. splicing) ovog gena na 5' UTR dovodi do nekoliko transkript varijanti.[1]
Interakcije
[уреди | уреди извор]Demonstrirano je da DDR2 ima protein-protein interakciju sa SHC1.[2]
Reference
[уреди | уреди извор]- ^ а б „Entrez Gene: DDR2 discoidin domain receptor family, member 2”.
- ^ Ikeda, Kazuo; Wang Li-Hsien; Torres Richard; Zhao Hong; Olaso Elvira; Eng Francis J; Labrador Pablo; Klein Rudiger; Lovett David; Yancopoulos George D; Friedman Scott L; Lin Hsin Chieh (2002). „Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen”. J. Biol. Chem. United States. 277 (21): 19206—12. ISSN 0021-9258. PMID 11884411. doi:10.1074/jbc.M201078200.
Literatura
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Spoljašnje veze
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