O2, O-2, o2, O2, or O2 may refer to:
- O2, the common allotrope of the chemical element oxygen
- O2, an EEG electrode site according to the 10–20 system
- SGI O2, a Unix workstation computer
- UOC O2, institutional repository of the Open University of Catalonia
- The O2, an entertainment district in London, England
- O2 Arena (Prague) or Sazka Arena, an arena in Prague, Czech Republic
- O2 Centre, an indoor shopping and entertainment centre on Finchley Road, London, England
- O2 Residence, a part of the Jumeirah Lake Towers in Dubai, United Arab Emirates
- O2 World (Berlin), an indoor arena in Berlin, Germany
- O2 World (Hamburg), an indoor arena in Hamburg, Germany
- Otoyol 2, a motorway in Turkey called "O2"
- The O2 (Dublin), the former name of 3Arena
- O2 (FireHouse album) (2000) album of the rock band FireHouse
- O2 (O-Town album) (2002) album by American boy band O-Town
- O2 (Tonéx album) (2002) album by Gospel singer Tonéx
- O2: Avalon Remixed, a 2002 album by Avalon
- O2 (Son of Dave album), 2006 album by Son of Dave
- "O2", a song by Orange Range from Panic Fancy
- "O2", a 2002 song by Sleater-Kinney from One Beat
- O2, trading name for Telefónica Europe, a European telecommunications provider
- O2 Store, a chain of retail stores owned and operated by Telefónica Europe, with regional subsidiaries:
- O2 (Ireland), merged into Three Ireland
- O2 (UK)
- O2 Czech Republic
- Telefónica Germany
- Telefónica Slovakia
- O2 Academy, a chain of music venues
- O2 Global Network, an international network for sustainable design
- O2 Wireless USA or H2O Wireless, a prepaid wireless service by Locus Telecommunications
- O2TV, a Russian independent socially political TV channel
- Cessna O-2 Skymaster, a military twin-engine light aircraft
- Douglas O-2, a military single-engine observation biplane
- O 2-class submarine, a class of submarines of the Royal Netherlands Navy
- Oldershaw O-2, a glider
- SP&S Class O-2, a 1910 steam locomotives class
- USS O-2 (SS-63), a 1918 United States O class submarine
- O-2, a pay grade in the US uniformed services