Nitroglycerin molecule Nitroglycerin , also known as nitroglycerine (UK spelling), trinitroglycerin , trinitroglycerine , 1 ,2 ,3-trinitroxypropane and glyceryl trinitrate , is a heavy , colorless , oily , explosive liquid obtained by nitrating glycerol . It is very dangerous and easy to detonate . It was synthesized in 1847 by Italian chemist Ascanio Sobrero . Alfred Nobel used it to make one of the most famous explosives in the world during 1867, named dynamite .
Nitroglycerine is also used in some medicines because it is a vasodilator . This means it makes the blood vessels get wider. That makes it easier for blood to flow through them.
Nitroglycerine is used mostly for angina and some heart attacks caused by coronary artery disease .[1] This is a disease that makes the blood vessels that bring blood to the heart become narrower. When the heart does not get enough blood and oxygen , a person can have angina (chest pain ) or a heart attack . Taking nitroglycerine makes the blood vessels get wider again, so more blood and oxygen can get to the heart.[1]
Nitroglycerin is sometimes used in emergencies for other medical conditions caused by narrow blood vessels.
Forms Targets
sGC
Activators/stimulators: Ataciguat
BAY 41-2272
BAY 41-8543
BAY 60-4552
BI-703704
Cinaciguat (BAY 58-2667)
GSK-2181236A
Praliciguat
Riociguat
Vericiguat
NO donors(prodrugs)
Nitrates : Diethylene glycol dinitrate (DEGDN)
Erythritol tetranitrate (ETN)
Ethylene glycol dinitrate (EGDN; nitroglycol)
Isosorbide mononitrate (ISMN)
Isosorbide dinitrate (ISDN)
Itramin tosilate
Mannitol hexanitrate
Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)
NCX-466
NCX-2216
NCX-4016
NCX 4040
NCX-4215
Nicorandil
Nipradilol (K-351)
Nitrate (NO− 3 )
Nitroatorvastatin (NCX-6560)
Nitroflurbiprofen (HCT-1026)
Nitrofluvastatin
Nitroglycerin (glyceryl trinitrate (GTN))
Nitropravastatin (NCX-6550)
Pentaerithrityl tetranitrate (PETN)
Propatylnitrate
Propylene glycol dinitrate (PGDN)
Sodium trioxodinitrate (Angeli's salt)
Tenitramine
Trolnitrate
Nitroso compounds/nitrites : Nitrite (NO− 2 ) ; O-Nitroso compounds (alkyl nitrites): Amyl nitrite (isoamyl nitrite, isopentyl nitrite)
Cyclohexyl nitrite
Ethyl nitrite
Hexyl nitrite
Isobutyl nitrite (2-methylpropyl nitrite)
Isopropyl nitrite
Methyl nitrite
n -Butyl nitrite
Pentyl nitrite
tert -Butyl nitrite; S-Nitroso compounds (thionitrites): LA810
S-Nitrosoalbumin (SNALB)
S-Nitrosated AR545C
S-Nitroso-N-acetylcysteine (SNAC)
S-Nitroso-N-acetylpenicillamine (SNAP)
S-Nitroso-N-valerylpenicillamine (SNVP)
S-Nitrosocaptopril (SNO-Cap)
S-Nitrosocysteine (SNC, CysNO, SNO-Cys)
S-Nitrosodiclofenac
S-Nitrosoglutathione (GSNO, SNOG)
SNO-t-PA
SNO-vWF; N-Nitroso compounds (e.g., nitrosamines): SIN-1A
Nitrosyl compounds: Metal nitrosyl complexes: Roussin's black salt
Roussin's red salt
Sodium nitroprusside (SNP)
NONOates (diazeniumdiolates): Diethylamine/NO (DEA/NO)
Diethylenetriamine/NO (DETA/NO)
GLO/NO
JS-K
Methylamine hexamethylene methylamine/NO (MAHMA/NO)
PROLI/NO
Spermine/NO (SPER/NO)
V-PYRRO/NO
Heterocyclic compounds: Furoxans: Furoxan
REC15/2739; Sydnonimines: Feprosidnine
Linsidomine (SIN-1)
Molsidomine (SIN-10)
Sydnonimine
Unsorted: Cimlanod
FK-409
FR144220
FR146881
N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide
Enzyme (inhibitors)
NOS
nNOS
3-Bromo-7-nitroindazole
3-Chloroindazole
3-Chloro-5-nitroindazole
5-Nitroindazole
6-Nitroindazole
7-Nitroindazole
A-84643
Aminoguanidine (pimagedine)
ARL-17477
Indazole
N5 -(1-Iminoethyl)-L-ornithine (L -NIO)
Nω -Methyl-L -arginine (L -NMA)
Nω -Propyl-L -arginine (L -NPA)
Nitroarginine (NNA, NOARG)
Pentamidine isethionate
TRIM
iNOS
1-Amino-2-hydroxyguanidine
2-Ethylaminoguanidine
2-Iminopiperidine
1400W
AEITU
Aminoguanidine (pimagedine)
AMT
AR-C 102222
BYK-191023
Canavanine
Cindunistat (SD-6010)
EITU
IPTU
MITU
N5 -(1-Iminoethyl)-L -ornithine (L -NIO)
N6 -(1-Iminoethyl)-L -lysine (L -NIL)
Nω -Methyl-L -arginine (L -NMA)
Ronopterin (VAS-203)
TRIM
eNOS
Aminoguanidine (pimagedine)
N5 -(1-Iminoethyl)-L -ornithine (L -NIO)
Nω -Methyl-L -arginine (L -NMA)
Nitroarginine (NNA, NOARG)
Unsorted
Asymmetric dimethylarginine (ADMA)
CKD-712
Guanidinoethyldisulfide (GED)
GW-273629
Indospicine
KD-7040
Nitroarginine methyl ester (NAME)
NCX-456
NXN-462
ONO-1714
VAS-2381
Arginase
ABH
Nω -Hydroxy-L -arginine (NOHA)
chlorogenic acid
ginseng
epicatechin
ornithine
norvaline
lysine
alpha aminoacids
CAMK
Others
Precursors: L -Arginine
Nω -Hydroxy-L -arginine (NOHA)
Indirect/downstream NO modulators: ACE inhibitors/AT-II receptor antagonists (e.g., captopril, losartan)
ETB receptor antagonists (e.g., bosentan)
L-Type calcium channel blockers (e.g., dihydropyridines: nifedipine )
Nebivolol (beta blocker )
PDE5 inhibitors (e.g., sildenafil )
non-selective PDE inhibitors (e.g., caffeine )
PDE9 inhibitors (e.g., paraxanthine)
cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)
Statins (e.g., simvastatin)