"Lorong pencakar langit" bergaya Internasional di sepanjang Sixth Avenue menghadap utara dari 40th Street menuju Central Park
Sixth Avenue – nama resminya Avenue of the Americas, meski nama ini jarang digunakan oleh warga New York[1] – adalah sebuah jalan raya di borough Manhattan, New York City. Lalu lintas di jalan ini bergerak ke utara atau "uptown". Jalan ini dijajari oleh pertokoan komersial di sepanjang pinggirannya.
Sixth Avenue berawal empat blok di bawah Canal Street, di Franklin Street di TriBeCa, tempat jalan Church Street terbagi dua menjadi Sixth Avenue di kiri dan lanjutan Church Street di kanan, kemudian berakhir di Canal Street. Mulai dari sini, Sixth Avenue melintasi SoHo dan Greenwich Village, langsung memisahkan Chelsea dari Flatiron District dan NoMad, melintasi Garment District dan menyusuri tepian Theatre District ketika membelah kawasan Midtown Manhattan.
Ujung utara Sixth Avenue terletak di Central Park South, di sebelah pintu masuk lalu lintas Artists Gate menuju Central Park di Center Drive. Bagian dari Sixth Avenue yang membentang ke utara Central Park dulunya bernama Lenox Avenue tahun 1887 dan Malcolm X Boulevard tahun 1987, sehingga sering memunculkan kebingungan di kalangan masyarakat.[2]
South St· Essex St · Ludlow St · Orchard St · Allen St · Forsyth St · Front St · Pearl St/Bowery· Mott St ·Mulberry St·City Hall Ln/Coenties Alley · Coenties Slip · William St · Centre Market Pl · Centre St · Broad St/Nassau St/Lafayette St · Whitehall St ·Broadway· Trinity Pl ·Church St ·University Pl ·West Broadway · MacDougal St/ · Patchin Pl · Varick St · Hudson St · Greenwich St · Washington St · Weehawken St ·West Side Elvtd Hwy/West St
Harlem River Dr · Audubon Ave · St. Nicholas Ave · Juan Pablo Duarte Blvd · Morningside Ave · Claremont Ave · Ft. Washington Ave · Pleasant Avenue ·Cabrini Blvd
Bridge St ·Brewers St/Stone St ·Wall St·Liberty St· Maiden Ln · Fulton St · Vesey St ·Ann St · Park Row ·Roosevelt St· Chambers St · Cherry St · Henry St · Worth St/Justice John M. Harlan Way/Ave of the Strongest · East Broadway · Doyers St/Bloody Angle · N. Moore St · Beach St · Canal St · Hester St · Grand St · Delancey St · Rivington St · Stanton St ·Houston St 1st–14th Sts — 1st St ·Bleecker St ·2nd St ·3rd St/Great Jones St ·4th St ·6th St ·Waverly Pl/Washington Square North ·Astor Pl/Washington Mews ·Gay St ·8th St/St. Mark's Pl/Greenwich Ave ·Christopher St ·Stuyvesant St ·10th St ·13th St ·14th St
15th–22nd Sts — 17th St 23rd–41st Sts — 23rd St·24th St ·25th St ·26th St ·27th St/Club Row ·28th St ·29th St ·30th St ·31st St ·32nd St/Korea Way ·33rd St ·34th St·35th St ·36th St ·37th St ·38th St ·39th St ·40th St ·41st St 42nd–59th Sts — 42nd St ·47th St ·50th St ·51st St ·52nd St/Swing Alley/St of Jazz ·53rd St ·54th St ·55th St ·57th St·59th St/Central Park South
60th–215th Sts — 66th St/Peter Jennings Way · 72nd St · 79th St · 85th St · 86th St · 96th St · 110th St/Cathedral Pkwy/Central Park North · 112th St · 116th St · 118th St · 122nd St/Mother Hale Way/Seminary Row · 125th St/Dr. Martin Luther King Jr. Blvd · 130th St/Astor Row · 132nd St · 139th St/Strivers' Row · 145th St · 155th St · Trans-Manhattan Expwy ·178th–179th St Tls· 181st St · 187th St · Bogardus Pl · Dyckman St
Miring menandakan jalan tidak ada lagi. Lihat pula:Commissioners' Plan of 1811 dan Daftar jalan eponim di New York City.