Protein-coding gene in the species Homo sapiens
Zinc finger NFX1-type containing 1 is a protein that in humans is encoded by the ZNFX1 gene.
[5]
Clinical significance
ZNFX1 deficiency in humans is associated with severe multisystem inflammatory disease.[6] Affected individuals may develop liver, lung or kidney failure, seizures and hemophagocytic lymphohistiocytosis (HLH) upon viral infections. Intermittent monocytosis is a hallmark laboratory finding in ZNFX1 deficiency. The disorder is thought to result from alterations in the half-life of the mRNA of interferon-stimulated genes (ISG) and is also associated with poorer clearance of viral infections in monocytes.