Wycliffe is a given name and surname.
A most notable holder of the name was John Wycliffe (also spelled Wyclif, Wycliff, Wiclef, Wicliffe, Wickliffe) (c. 1320s – 31 December 1384) who was an English scholastic philosopher, theologian, Biblical translator, reformer, and seminary professor at Oxford. He was an influential dissident within the Roman Catholic priesthood during the 14th century. Among other things, Wycliffe Hall, Oxford; Wycliffe College, Toronto; Wycliffe College, Gloucestershire; and the 1841 ship John Wickliffe are named after him.