Improve & update coverage for general articles such as Biophysics, core articles listed at Outline of biophysics, etc
Improve individual articles on biophysics topics
Add more international coverage for lists of biophysicists, journals, organizations, etc - e.g. use [1] for European societies, use List of members of the National Academy of Sciences (Biophysics_and_computational_biology) (especially the redlinks), list of NAS Hollaender awards [2] and Biophysical Soc Founder's Award [3] and National Lecturers [4] for US biophysicists, similar things in other countries
Upload biophysics-related media to Wikimedia Commons that can be used to illustrate specific articles, such as Optogenetics, and link them
Make specific articles on biophysical results or methods more complete and up-to-date, such as adding motions to Ribosomes, adding much more on macromolecular crystallography to X-ray crystallography, adding more on the new developments in Cryo-electron microscopy
Sort out biological crystallography from x-ray crystallography (now nearly all small-molecule), and generalize Protein crystallography to macromolecular by including nucleic acids; expand the crystal structure part of Resolution (electron density) to match the EM part
For the whole topic of allostery, simplify & clarify language, and unify either by providing a central article (perhaps with linked child articles) or by merging the current many "Allosteric ...."
Add macroscale subjects such as biomechanics to coverage

Here are some tasks awaiting attention: