WD and tetratricopeptide repeats 1 | |||||||
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Identifiers | |||||||
Symbol | WDTC1 | ||||||
NCBI gene | 23038 | ||||||
HGNC | 29175 | ||||||
RefSeq | NM_015023 | ||||||
UniProt | Q8N5D0 | ||||||
Other data | |||||||
Locus | Chr. 1 p35.3 | ||||||
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WDTC1 ("Adipose") is a gene associated with obesity.[1][2][3]
WDTC1 is a gene that codes for a protein acting as a suppressor in lipid accumulation. WDTC1 protein consists of seven WD40 domains, three transient receptor potential channel protein-protein interaction domains, DDB1 binding elements, and a prenylated C-terminus.[4] Reduced expression or disruption of WDTC1 gene is associated with obesity, increased triglyceride accumulation, and adipogenesis. WDTC1 is a factor in a complex composed of DDB1, CUL4, and ROC1 that restricts transcription in adipogenesis. [5]
Studies of phenotype of mice showed that having a loss of an allele resulted in obesity and poor metabolic profiles. Transgenic expression of the WDTC1 gene in mice showed the opposite effect with mice having less adipose.[6]