VitD-bind_III | |||||||||
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Identifiers | |||||||||
Symbol | VitD-bind_III | ||||||||
Pfam | PF09164 | ||||||||
Pfam clan | CL0282 | ||||||||
InterPro | IPR015247 | ||||||||
SCOP2 | 1kxp / SCOPe / SUPFAM | ||||||||
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In molecular biology, Vitamin D binding protein domain III protein domain is predominantly found in Vitamin D binding proteins (DBP). Vitamin D-binding protein (DBP)(also referred to as Gc-globulin) is synthesized primarily in the liver. This entry outlines the domain III of DBP. Domain III (amino acid 379–458) is G-actin binding region located in the C-terminal. Domain (amino acids 373 to 403). This protein is found ubiquitously in vivo in significant quantities and can be detected in all fluid compartments.[1] During acute phase inflammatory response, DBP levels tend to increase.
DBP has several functions. More precisely, domain III has the specific function of being an extracellular scavenger for G-actin released from necrotic cells at sites of tissue injury.[1]
DBP domain III has a multihelical structure. It is required for formation of an actin 'clamp', allowing the protein to bind to actin.[2] This protein is a member of the albumin gene family and has the characteristic multiple disulfide-bonded, triple domain structure.