VCF may refer to:

Organizations

• Valencia CF, a Spanish professional football club in Valencia
• Victory (church) (formerly VCF), an evangelical Protestant church based in the Philippines

Technology

• Variant Call Format, the format of a text file used in bioinformatics for storing gene sequence variations
• vCard, a file format standard for electronic business cards
• Virtual Case File, a software application developed by the United States Federal Bureau of Investigation
• VMware Cloud Foundation, an infrastructure platform for hybrid cloud management of the VMware Infrastructure product line
• Voltage-controlled filter, an electronic filter whose operating characteristics can be set by an input control voltage
• Volume correction factor, a standardized computed factor used to correct for the thermal expansion of fluids

Other

• September 11th Victim Compensation Fund, an act of the US Congress to compensate the victims of the September 11 attacks
• VCF, one of several brands of spermicide
• Vintage Computer Festival, an international event celebrating the history of computing