The United States Post Office and federal courthouse in Charleston, South Carolina is one of many National Register of Historic Places listings in Charleston County, South Carolina.

The building, completed in 1896 in the Renaissance Revival style, was designed by Charleston architect John Henry Devereux using gray granite. The design includes a square tower, heavy balustrated balconies, rusticated base and quoins, great double doors, and high and broad steps meant to resemble an Italian Renaissance palace.

The building continues to serve as the federal court for the Charleston Division of the United States District Court for the District of South Carolina. The courthouse has expanded many times since its construction both to the south (into the late 20th century Holling Judicial Center) and to the west, incorporating several much older buildings on Broad St. Because of its location at the southwest corner of Broad and Meeting Sts., the federal courthouse makes up one-quarter of the Four Corners of Law, an intersection in downtown Charleston, around which are buildings representing municipal law (city hall), county law (the historic county courthouse), federal law, and church law (St. Michael's Episcopal Church).