Names | |
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Preferred IUPAC name
(Tetradecylsulfanyl)acetic acid | |
Other names
1-(Carboxymethylthio)tetradecane
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Identifiers | |
3D model (JSmol)
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Abbreviations | TTA; CMTD |
ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C16H32O2S | |
Molar mass | 288.49 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Tetradecylthioacetic acid (TTA) is a synthetic fatty acid used as a nutritional supplement.
TTA acts as a peroxisome proliferator-activated receptor alpha (PPARα) agonist and increases mitochondrial fatty acid oxidation in vitro.[1] In rodent studies, TTA has been reported to have other activities such as reducing inflammation[2] and preventing high fat diet induced adiposity and insulin resistance.[3]
In human clinical study, there have been mixed observations in preliminary studies. One Phase I study showed no significant changes in the blood lipids or free fatty acids[4] and another showed that TTA attenuates dyslipidemia in patients with type 2 diabetes mellitus.[1]