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I would like to know about the history of a cytotoxic T cell. I can't find anything on the web!== CD8+ T cells == If I remember correctly, CD8+ T cells equals cytotoxic T cells. The article is not clear on this point. / Habj 16:34, 21 December 2005 (UTC)
The mention of pathogenesis in various disease states is a good idea, although I feel that perhaps the pathogenesis section just needs a good introduction into the generalised role of cytotoxic T cells (i.e. they kill infected cells, but they have also been implicated in the pathogenesis of various illnesses). Is the discussion of the role of platelets in a Hepatitis B infection beginning to deviate from the purpose of this article? Wouldn't that specific result (especially since it isn't in a review) should remain in the pathogenesis section of Hepatitis B? Volantares 10:49, 6 July 2006 (UTC)
all the development can be described with all T lympocytes in the T cell article. Seems pointless to repeat it slightly differently in lots of places.
I think it is worth noting that this cell (particularly CD8 T Cells) are important in the small, very rare, population of people who have HIV but are immune (or at least very highly protected from) AIDS. —The preceding unsigned comment was added by 68.205.70.254 (talk) 05:15, 29 March 2007 (UTC).
This paragraph only talks about the Instructive Model Pathway for T cell development. There is another pathway, the Stochastic Pathway, which needs to be added and a statement that there is no general consensus over which one is correct, although most university teach the Instructive pathway. Scubafish 10:48, 29 May 2007 (UTC)
Then why don't you change it you friggin Know-it-all75.155.134.185 (talk) 02:43, 29 December 2008 (UTC)
Uh, unless I'm wrong, I find the first diagram a little misleading. It implies that it is the process of antigen presentation with the peptide that induces a T-cell to become CD4 or CD8 whereas it is infact the process of positive selection where if the T-cell interacts with MHCI then it is 8 and MHCII then it is 4, regardless of the antigen it encounters later on. —Preceding unsigned comment added by Cacofonie (talk • contribs) 12:38, 3 June 2008 (UTC)
Actually, according to Janeway's Immunology, it's even more complex: double positive T cells randomly become single positive (SP) CD4+ or SP CD8+ cells, and then they will only survive if they have kept the marker that can function with the type of MHC their TCR recognizes; so, if a T cell's TCR recognizes CMH II and the T cell randomly chooses to keep CD8 and not CD4, it will die; thus, at this late stage during differentiation, T cells have a 1/2 chance of making the wrong random choice, and half of them die.
Also: "When these cells are infected with a virus (or another intracellular pathogen), the cells degrade foreign proteins via antigen processing." This is misleading: cells degrade all the time their proteins when they are recycled, not just when they are infected. Self peptides are presented on the surface of uninfected or infected cells, but T cells that could recognize these are destroyed during negative selection in the thymus. However, new, pathogen-derived peptides are presented on the surface of infected cells, and there is a proportion of immuno-competent mature T cells that can recognize these and hence detroy the infected cells. —Preceding unsigned comment added by 140.77.192.140 (talk) 16:28, 9 March 2010 (UTC)
Yes, I erased this diagram 2 hours ago because it is deeply wrong. Lymphocytes do not differentiate to CD4+ or CD8+ on the periphery, this is a solely thymic process. —Preceding unsigned comment added by 78.130.117.142 (talk) 17:43, 21 January 2011 (UTC)
I want to know what is the relationship between Killer T cells and the thymus. — Preceding unsigned comment added by 96.252.155.69 (talk) 18:07, 6 May 2012 (UTC)
I thought Positive selection was when T-cells in the thymus are selected based on their TCR for their ability to recognize MHC class molecules. The article makes it seem like positive selection kills off those T-cells that bind too weakly, which does occur, but that is not positive selection I believe.
bruh, the cells r epic — Preceding unsigned comment added by 76.24.214.142 (talk) 14:56, 28 January 2021 (UTC)
The second paragraph of the activation section currently says: "The threshold for activation of these cells is very high, and the process can occur via two pathways: thymus-independent (by infected APCs) or thymodependent (by CD4+ T cells). In the thymus-dependent pathway, because the APC is infected, it is highly activated and expresses a large number of co-receptors for coactivation. If APCs are not infected, CD4 cells need to be involved…"
In the second sentence, shouldn’t it say "thymus-independent" instead of "thymus-dependent"? It continues to say “because the APC is infected” and in the first sentence of the paragraph it says "thymus-independent (by infected APCs)". Also, in the third sentence it continues by saying “If APCs are not infected, CD4 cells need to be involved”, implying this is the alternate thymus-independent pathway even though the first sentence says “thymodependent (by CD4+ T cells)”. A bit confusing if you ask me. — Preceding unsigned comment added by CarlosArceDeza (talk • contribs) 16:36, 26 April 2022 (UTC)