SprD | |
---|---|
Identifiers | |
Symbol | SprD |
Rfam | RF01828 |
Other data | |
RNA type | Gene |
Domain(s) | Staphylococcus aureus |
PDB structures | PDBe |
In molecular biology SprD (Small pathogenicity island RNA D) is a non-coding RNA expressed on pathogenicity islands in Staphylococcus aureus.[1] It was identified in silico along with a number of other sRNAs (SprA-G) through microarray analysis which were confirmed using a Northern blot.[2] SprD has been found to significantly contribute to causing disease in an animal model.[1]
SprD is located between genes scn and chp in the innate immune evasion cluster (IEC) of the S. aureus genome. Its placement within this region was the first indication of a virulence-factor regulatory function.[1]
SprD binds with sbi (Staphylococcus aureus binder of IgG)[3] mRNA which encodes an immune evasion protein. It occludes the Shine-Dalgarno sequence and the initiation codon of sbi, forming a sbi mRNA-SprD duplex repressing the translation of the mRNA.[1]
sbi protein interferes with the host's innate immune response by binding Factor H, Complement component 3 and IgG.[3][4]