Sean Kelly may refer to:

Sports

• Sean Kelly (cyclist) (born 1956), Irish professional road bicycle racer
• Sean Kelly (Scottish footballer) (born 1993), Scottish footballer (St. Mirren FC, AFC Wimbledon)
• Seán Kelly (Galway Gaelic footballer) (born 1997)
• Seán Kelly (Kerry Gaelic footballer) (1925–2012)
• Sean Dylan Kelly (born 2002), American motorcycle racer
• Sean Kelley (sportscaster), American sportscaster
• Sean Wirtz (born 1979), figure skater who has competed as Sean Kelly

Music

• Sean Kelly (Australian musician) (born 1958), founder of the Australian 1980s band Models
• Sean Kelly, Australian guitarist and member of TISM between 1983 and 1991
• Sean Kelly (Canadian musician), founder of band Crash Kelly
• Sean Kelly, singer and guitarist for The Samples

Other

• Seán Kelly (Irish politician) (born 1952), Irish Member of the European Parliament
• Sean Kelly (Irish republican) (born 1972), IRA Shankill Road bomber
• Sean Kelly (writer) (born 1940), Canadian author, wrote for National Lampoon
• Sean Dorrance Kelly, professor of philosophy at Harvard University
• Sean Kelly Gallery in New York
• Sean Kelly, stand up comedian and presenter of the television series Storage Hunters
• Sean Kelly, New Zealand fashion designer who won Project Runway season 13