Renal cell carcinoma with t(6;11) translocation | |
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Specialty | Oncology/nephrology |
Renal cell carcinoma with t(6;11) translocation or TFEB-amplified Renal Cell Carcinomas is rare subtype of renal cell carcinoma. The t(6;11)(p21;q12) translocation fuses the Alpha (MALAT1) gene with the TFEB transcription factor gene, resulting in upregulated expression of TFEB which leads to expression of melanocytic markers.[1]
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Glandular and epithelial cancer | |||||||||||||||||||||||||||||||
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Epithelium |
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Glands |
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