Protein-coding gene in the species Homo sapiens
RNASE1 |
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![](https://upload.wikimedia.org/wikipedia/commons/thumb/c/c1/Protein_RNASE1_PDB_1dza.png/250px-Protein_RNASE1_PDB_1dza.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1DZA, 1E21, 1H8X, 1Z7X, 2E0J, 2E0L, 2E0M, 2E0O, 2K11, 2Q4G, 3F8G, 4KXH |
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Identifiers |
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Aliases | RNASE1, RAC1, RIB1, RNS1, ribonuclease A family member 1, pancreatic |
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External IDs | OMIM: 180440 MGI: 97919 HomoloGene: 7919 GeneCards: RNASE1 |
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Wikidata |
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Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[5][6]
Function
This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[6]