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Routes of administration | Oral |
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Formula | C19H21NO2 |
Molar mass | 295.382 g·mol−1 |
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Density | 1.2 g/cm3 |
Boiling point | 446 to 536 °C (835 to 997 °F) [1] |
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N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine.[2][3] In rodents it has been shown to produce hyperactivity, stereotypy, hypothermia, antinociception, and penile erection, among other effects.[4][5][6][7] Notably, its effects on locomotion are biphasic, with low doses producing inhibition and catalepsy and high doses resulting in enhancement of activity.[8] This is likely due to preferential activation of D2/D3 autoreceptors versus postsynaptic receptors,[9] the latter of which overcomes the former to increase postsynaptic dopaminergic signaling only with high doses.