Pick 6 may refer to:
- Pick 6 (horse racing), a wager in which a bettor picks one horse in each of six races
- Pick 6 (lottery), a game in which six numbers are picked
- Pick-six, an interception returned for a touchdown in gridiron football
- "Pick Six", a ranking system used by Ring of Honor to determine championship contenders
This disambiguation page lists articles associated with the title Pick 6.
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