Protein arginine methyltransferase 8 is a protein that in humans is encoded by the PRMT8 gene.[1] Arginine methylation is a posttranslational modification involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction and protein compartmentalization.[1] PRMT8 binds and dimethylates Ewing sarcoma breakpoint region 1 (EWS) protein.[2]