Protein-coding gene in the species Homo sapiens
DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the POLR2J gene .
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene exists as a heterodimer with another polymerase subunit; together they form a core subassembly unit of the polymerase. Two similar genes are located nearby on chromosome 7q22.1 and a pseudogene is found on chromosome 7p13.[ 5]
POLR2J has been shown to interact with:
^ a b c GRCh38: Ensembl release 89: ENSG00000005075 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039771 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Entrez Gene: POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa" .
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^ Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits" . J. Biol. Chem . 272 (27): 16815–21. doi :10.1074/jbc.272.27.16815 . PMID 9201987 .
^ Corbi N, Di Padova M, De Angelis R, Bruno T, Libri V, Iezzi S, Floridi A, Fanciulli M, Passananti C (October 2002). "The alpha-like RNA polymerase II core subunit 3 (RPB3) is involved in tissue-specific transcription and muscle differentiation via interaction with the myogenic factor myogenin" . FASEB J . 16 (12): 1639–41. doi :10.1096/fj.02-0123fje . PMID 12207009 . S2CID 30243193 .
^ Durrin LK, Krontiris TG (June 2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics . 79 (6): 809–17. doi :10.1006/geno.2002.6772 . PMID 12036295 .
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