Protein-coding gene in the species Homo sapiens
Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.[5][6][7]
Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of Glycosylphosphatidylinositol (GPI) anchored proteins.[7]
This enzyme has been extracted from the venom of the wasp species Polistes major major.[8]