Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1gene.[5][6][7]
Function
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.[8] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[7]
^Kishi F (November 1994). "Isolation and characterization of human Nramp cDNA". Biochemical and Biophysical Research Communications. 204 (3): 1074–80. doi:10.1006/bbrc.1994.2572. PMID7980580.
^Teras IuKh, Ryĭgas EM, Kazakova II, Ranne KhP, Trapido LE (1980). "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases]". Terapevticheskii Arkhiv. 52 (3): 123–5. PMID7385031.
Further reading
Blackwell JM, Searle S, Mohamed H, White JK (January 2003). "Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story". Immunology Letters. 85 (2): 197–203. doi:10.1016/S0165-2478(02)00231-6. PMID12527228.
Vidal SM, Malo D, Vogan K, Skamene E, Gros P (May 1993). "Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg". Cell. 73 (3): 469–85. doi:10.1016/0092-8674(93)90135-D. PMID8490962. S2CID54294811.
Kishi F, Nobumoto M (1996). "Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes". Immunology Letters. 47 (1–2): 93–6. doi:10.1016/0165-2478(95)00070-L. PMID8537108.
Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E (September 2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID10967134. S2CID11308779.
Bassuny WM, Ihara K, Matsuura N, Ahmed S, Kohno H, Kuromaru R, Miyako K, Hara T (July 2002). "Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes". Immunogenetics. 54 (4): 282–5. doi:10.1007/s00251-002-0459-3. PMID12136340. S2CID19801943.
Puzyrev VP, Freĭdin MB, Rudko AA, Strelis AK, Kolokolova OV (2002). "[Polymorphisms of the candidate genes for genetic susceptibility to tuberculosis in the Slavic population of Siberia: a pilot study]". Molekuliarnaia Biologiia. 36 (5): 788–91. PMID12391841.