ncRNA Repressor of NFAT (nuclear factor of activated T cells) | |
---|---|
Identifiers | |
Symbol | NRON |
Rfam | RF00636 |
Other data | |
RNA type | Gene |
Domain(s) | Eukaryota |
SO | SO:0001263 |
PDB structures | PDBe |
NRON also known as ncRNA repressor of the nuclear factor of activated T cells is a non-coding RNA involved in repressing NFAT.[1] The function of this ncRNA was identified by a large-scale screen of 512 non-coding RNAs discovered in earlier EST sequencing projects.[2][3]
Each of the RNAs that were conserved between human and mouse were knocked down using shRNAs. The resulting cell-lines were screened for changes in activity of NFAT.