Mike Walker is the name of:

Sports

• Mike Walker (rugby union) (1930–2014), Scottish rugby union player
• Mike Walker (English footballer) (born 1945), former English footballer
• Mike Walker (Welsh footballer) (born 1945), former Welsh footballer and manager
• Mike Walker (Canadian football) (born 1958), Canadian football player
• Mike Walker (pitcher, born 1965), American baseball pitcher
• Mike Walker (pitcher, born 1966), American baseball pitcher
• Mike Walker (infielder) (born 1988), Australian baseball infielder
• Mike Walker (tennis) (born 1966), Welsh tennis player
• Mike Walker (canoeist) (born 1977), New Zealand kayaker

Music

• Mike Walker (jazz guitarist) (born 1962), jazz guitar player from Salford in England
• Mike Walker (singer), country music artist, or his self-titled debut album

Other

• Mike Walker (columnist) (1946–2018), gossip columnist for the National Enquirer
• Mike Walker (radio dramatist), dramatist for BBC radio
• Mike Walker (engineer) (1911–2013), designer and engineer employed with Remington Arms