Michael Panopoulos is an Australian-Greek association football player. He currently plays for Oakleigh Cannons, for whom he is also assistant-manager.

Panopoulos began his career as a youth player with Heidelberg United in Australia, though in 1993 he was offered a professional contract with Aris Thessaloniki F.C. in the Greek Super League. Whilst at the Greek club Panopoulos played in the UEFA cup and a was a losing finalist in the Greek Football Cup.

Strong performances by Panopoulos for the Greek club led to a £1 million transfer to Portsmouth F.C. in August 2000; a club record fee. Panopoulos spent three years at Portsmouth, helping the club to promotion to the FA Premier League.

Panopoulos transferred from Portsmouth to Dunfermline F.C. in the Scottish Premier League. After leaving Scotland he transferred to South Melbourne FC and then made a return to Greece with Kerkyra F.C. That was followed by a move back to Autralia, with Oakleigh Cannons of the Victorian Premier League.